Back to search results

PhD Studentship: Finding New Antibiotics in the Soil Microbiota

University of East Anglia - John Innes Centre

Qualification Type: PhD
Location: Norwich
Funding for: UK Students, EU Students, International Students
Funding amount: See advert details
Hours: Full Time
Placed On: 25th November 2021
Closes: 17th January 2022
Reference: MALONE_J22MMB

The increase in drug-resistant bacterial infections is a major global health threat. This crisis is exacerbated by a lack of new antibiotics, caused by multiple factors including the frequent rediscovery of known antibiotics. The soil microbiota is a rich source of natural product molecules, with soil bacteria producing the majority of current clinical antimicrobials. The vast genetic diversity within the soil microbiota means that many novel, clinically relevant natural products undoubtedly remain to be identified. However, to fully exploit this natural resource we both need to identify efficacious antimicrobials, and effectively minimise rediscovery. The genomic era provides an incredible opportunity to revitalise the antibiotic pipeline and guide the discovery of new antibiotic classes.

Our labs in the John Innes Centre, an internationally recognised centre of excellence for microbiology and plant sciences, have developed an effective, high-throughput pipeline for the identification and characterisation of biologically effective bacterial natural products. By pairing antimicrobial discovery with advanced data analysis we ensure that novel pathways and products are prioritised, and minimise antibiotic rediscovery.

In this project, the student will exploit the extensive soil microbial isolate libraries and discovery pipeline emerging from our recent research to identify and characterise new, clinically efficacious antimicrobial molecules. The student will receive training in advanced molecular microbiology and bacterial genetic manipulation, alongside cutting-edge organic chemistry techniques including LC-MS-based metabolomics, bioassay-guided fractionation and structural elucidation using 2D NMR. Throughout the project, the student will receive extensive training in the analysis of microbial genomes, statistics, phylogenetics and other bioinformatic techniques, as well as transferable soft-skills with broad applicability to many employment areas.

The Microbes, Microbiomes and Bioinformatics (MMB) Doctoral Training Partnership (DTP) is open to UK and international candidates with an undergraduate degree relevant to the scope of the programme for entry in October 2022 and offers postgraduates the opportunity to undertake a 4-year PhD research project funded by the UKRI Medical Research Council to advance the training of students in microbiology, with an emphasis on microbial bioinformatics.

This project has been shortlisted for funding by the MMB DTP programme. Interviews for shortlisted candidates will take place on Tuesday 15 or Wednesday 16 February 2022.

This MMB DTP is committed to equality, diversity, widening participation and inclusion in all areas of the programme. We encourage enquiries and applications from all sections of the community, regardless of gender, ethnicity, disability, age, sexual orientation, and transgender status. We value an aptitude for computer-based analysis, curiosity, and independence of thought, plus a commitment to work across the boundaries between the laboratory and bioinformatics to deliver high-impact research. We welcome applicants from low- and middle-income countries.

For information on eligibility and how to apply: https://www.uea.ac.uk/research/research-with-us/postgraduate-research/latest-phds-and-research-studentships/partnerships-in-doctoral-training

Primary Supervisor :  Dr Jacob Malone (JIC)

Start date: 1 October 2022

For more information on this project, please visit http://www.uea.ac.uk

This project is awarded with a 4-year MMB DTP PhD studentship, which includes support for a maintenance stipend, provided over four years, full tuition fees and research and training costs.

Studentship funding will not normally cover costs associated with visa or health surcharges, or additional costs associated with entry to, and living in the UK.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of East Anglia

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge