Back to search results

PhD Studentship Opportunity: Neuroinflammation, sleep and dementia: strategies to reduce symptoms and disease progression

University of Surrey - Faculty of Health and Medical Sciences

Qualification Type: PhD
Location: Guildford
Funding for: UK Students
Funding amount: The successful candidates will receive a stipend for 3 years (current rate £15,609 pa). In addition, all course (£4,500 pa) and bench fees will be provided.
Hours: Full Time
Placed On: 25th November 2021
Closes: 4th January 2022
Reference: PGR-2122-076

Neuroinflammation, sleep and dementia: strategies to reduce symptoms and disease progression

Supervisor 1: Prof Derk-Jan Dijk 

Supervisor 2: Dr Natalie Riddell

The overarching aim of the project is to better understand the mechanisms linking neuroinflammation, sleep, and in particular, Rapid-Eye-Movement (REM) sleep, in the context of dementia.

Neuroinflammation driven by microglial cells is a key cellular hallmark of dementia. Neuroinflammation correlates with tau pathology and predicts cognitive decline and the severity of Alzheimer’s disease. Sleep disturbances are a modifiable risk factors for Alzheimer’s disease and strategies to improve sleep are promising interventions. In humans, REM sleep is a significant risk factor for dementia. However, the role of REM sleep in dementia is unknown and a better understanding of the cellular mechanisms linking sleep, brain function, neuroinflammation and other hallmarks of disease is required to develop effective treatments for dementia.

This project will further characterise the impact of REM sleep on neuroinflammation in older human participants who are either cognitively intact or have mild cognitive impairment and dementia. Sleep structure (NREM and REM sleep), sleep disorders (e.g. sleep apnoea), EEG and cognitive assessments will be undertaken. Blood based biomarkers for neuroinflammation, neurodegeneration and peripheral inflammation will be investigated using biochemical techniques and state-of-the-art approaches, such as RNA sequencing and proteomics, to provide a comprehensive characterisation of the effects of sleep on cellular aspects associated with neuroinflammation.

The PhD candidate will be based at the Surrey Sleep Research Centre and the Section of Immunology within the Faculty of Health and Medical Sciences (FHMS) under the supervision of Prof Derk-Jan Dijk and Dr Natalie Riddell. The candidate will benefit from an extensive training in integrative physiology, immunology, and neuroscience focusing on Alzheimer’s disease and other dementia syndromes.

Entry requirements

Applicants are expected to hold a good honours degree (upper second) in an appropriate discipline

IELTS Academic: 6.5 or above (or equivalent) with 6 in each individual category.

How to apply

Must match a PGR programme as listed on our website. Please check that your start date corresponds with the start dates available on the programme page. Applications should be submitted via the Biosciences and Medicine PhD programme page on the "Apply" tab. Please clearly state the studentship title and supervisor on your application

Funding

This is a fully funded PhD opportunity. The successful candidates will receive a stipend for 3 years (current rate £15,609 pa). In addition, all course (£4,500 pa) and bench fees will be provided.

Godfrey Blott PhD studentship (sponsored by a philanthropic gift and the University of Surrey’s Faculty of Health and Medical Sciences)

Directly Funded Project for UK Students

Application enquiries

For application enquiries, please contact either Dr Natalie Riddell on email n.riddell@surrey.ac.uk or call 01483 686475 OR Prof Derk-Jan Dijk on email d.j.dijk@Surrey.ac.uk or call 01483 689341

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Surrey

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge