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PhD Studentship: Investigating the Role of Food Bioactives in Modulating the Gut Microbiota-to-brain Signalling

University of East Anglia - Medicine

Qualification Type: PhD
Location: Norwich
Funding for: UK Students
Funding amount: please see advert text
Hours: Full Time
Placed On: 17th December 2021
Closes: 14th February 2022
Reference: VAUZOURD_U22FMH

Applications are invited for a PhD studentship jointly funded by the Faculty of Medicine and Health and the French company Activ’Inside working under the supervision of Dr David Vauzour and Pr Michael Müller.

There has been increasing interest in the novel association between the gut microbiome and cognitive decline, suggesting that the gut microbiome may modulate host brain function via a microbiome–gut–brain axis. Gut microbes impact human health and disease at least in part by metabolising dietary and host-derived substrates and generating biologically active compounds including signalling molecules, biological precursors, and toxins. Interestingly, alterations in the gut microbiota composition and their metabolites (in combination with the amount and composition of foods) can influence (positively and negatively) permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neural injury, and ultimately neurodegeneration. This project will extend our ongoing programme of work in the gut-brain axis by investigating the role of food bioactives on gut microbiota structure and metabolism by using cutting-edge methods including shotgun metagenomics and targeted metabolomics and utilising bio-archived and newly collected bio-fluids (faeces, blood, urine) from highly characterised longitudinal and clinical cohorts.

The project should appeal to candidates interested in gut physiology, nutrition, metabolism and neuroscience in preventing age-related cognitive decline and dementia. The student will join the Norwich Medical School which provides a supportive research environment and access to experienced researchers. The student will receive training in targeted metabolomics, metagenomics, and computational modelling (machine learning, MRI scan analyses). In addition to their research the student will be provided with training in scientific writing, presentation, data management, statistical analysis and will be encouraged to attend and present at national and international conferences.

Primary Supervisor:  Dr David Vauzour

Start date: June 2022

For more information on this project, please visit http://www.uea.ac.uk

This PhD project is in a competition for a Faculty of Medicine and Health and the French company Activ’Inside funded studentship. Funding is available to UK applicants and comprises home tuition fees and an annual stipend of £16,565 for 3 years.  Applicants who are not eligible for home tuition fees are welcome to apply but they will be required to fund the difference between home and international tuition fees. Details of the University’s tuition fees are available at https://www.uea.ac.uk/about/university-information/finance-and-procurement/finance-information-for-students/tuition-fees.

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