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Research Associate

Imperial College London - Department of Life Sciences - Faculty of Natural Sciences

Location: London
Salary: £41,593 to £49,210 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 21st December 2021
Closes: 31st January 2022
Job Ref: NAT01038
 

Location: South Kensington Campus

A Research Associate post is available in the research group of Dr. Nikolai Windbichler (https://www.windbichlerlab.org/) working in collaboration with Dr. Angela Meccariello at Imperial College. Our joint research aims to build and improve gene drive systems, based on the use of CRISPR/Cas, as well as apply other genome editing technologies for genetic insect control.

We are looking for highly motivated individual and a team player who has previous experience with Drosophila genetics (or of other insects such as mosquitoes or medflies) and also a strong background in molecular/synthetic biology and is enthusiastic about entering the field of genetic control and gene drives. Some experience with genomics (e.g. RNAseq analysis) is a bonus but not essential.

You will help produce independent and original research as part of a team of researchers and technicians funded by the BBSRC and aimed at building and testing novel types of gene drives in the devastating global agricultural pest species Ceratitis capitata (the medfly) and other pests and also in the Drosophila melanogaster model.

You will design a range of synthetic DNA constructs and test their performance in transgenic insects. You will use genomics to develop tissue-specific drivers for novel gene drive strategies and identify targetable sequences in insect genomes. You will assess the suitability of such traits with regards to insect fitness and perform genetic analyses of transgenic insects to assess the propensity for the Super-mendelian transmission of such constructs on both the individual and population level. The project is part of a wider collaborative network and thus the role will involve a high degree of teamwork and interdisciplinary research.

Duties and responsibilities

  • To perform experiments and to produce data to analyse gene drive constructs
  • To identify and develop suitable techniques, models and methods, for the collection and analysis of data
  • To take initiatives in the planning of research and appropriate experiments
  • To prioritise tasks within agreed work schedule
  • To participate in and organise duties associated with research support, including various laboratory-related rotas
  • To contribute to the preparation of grant reports to funder, scientific publications and regular technical updates.
  • To collaborate with other allied scientists within Imperial College and elsewhere in London and abroad as appropriate.

Essential requirements

  • Research Associate: PhD (or equivalent) in Biological Sciences or a related scientific discipline
  • Research Assistant: Near completion of a PhD (or equivalent) in Biological Sciences or a related scientific discipline
  • Demonstrable experience of working with either Drosophila or other insects
  • High level of expertise and skills in molecular/synthetic biology
  • A successful track record of academic publications commensurate with experience
  • Practical experience of working within a highly competitive research environment
  • Good knowledge of insect genetics and transgenesis
  • Excellent verbal and written communication skills are required
  • Ability to work with little supervision and show initiative with research

Further Information

This is a full time, fixed term position based for 36 months, based at South Kensington Campus.

*Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.

Should you require any further details on the role please contact: [Nikolai Windbichler] – [n.windbichler@imperial.ac.uk].

Closing date: 31/01/2022

To apply, visit www.imperial.ac.uk/jobs and search by the job reference NAT01038.

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