Back to search results

Postdoctoral Research Associate

King's College London - Centre for Craniofacial and Regenerative Biology

Location: London
Salary: £39,345 to £41,517 including London Weighting Allowance
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th January 2022
Closes: 30th January 2022
Job Ref: 033825
 

Job description

A postdoctoral research associate position is available in the Knight group to work on a Leverhulme Trust funded project to understand how ageing affects muscle stem cell function. Candidates should have a strong background in zebrafish genetics, molecular biology and imaging and be able to apply an analytical and modelling approach to understand how ageing alters muscle stem responses to injury.

Using live cell imaging, single cell gene expression analysis and mathematical modelling the project aims to identify age-related cues that regulate how muscle stem cells respond to injury. This will be achieved by identifying genes showing age-related changes in muscle stem cells of zebrafish genetic models of ageing. Candidate ageing-associated genes will then be evaluated for their role in regulating muscle stem cell behaviour during regeneration by gene manipulation and imaging of cell behaviour by multiphoton and light-sheet microscopy.

The Knight group utilise live cell imaging and molecular profiling to define the key regulators of muscle homeostasis and repair in the context of disease and ageing. A major focus of the group is to combine descriptors of cell behaviour with molecular readouts for establishing mathematical models of tissue regeneration. The project is a collaboration with Dr. Ann Babtie at Imperial College London and Professor Ivo Sbalzarini at TU Dresden, Germany.

The Knight group is based in the Centre for Craniofacial and Regenerative Biology at Guy’s Hospital. The Centre combines strengths in tissue engineering and use of animal models for understanding human disease and regeneration. The post holder will be integrated into a welcoming and friendly environment with strong links to other departments at the Guy’s campus. 

The post holder will need to have had experience of working with zebrafish, performing live cell imaging and analysing gene function. Ideally they will also have experience of using computer languages to analyse gene expression datasets and imaging data.  

This post will be offered on an a fixed-term contract for 3 years

This is a full-time post - 100% full time equivalent

Key responsibilities

  • Perform experiments at the direction of the line manager and at their own initiative to advance the goals of the project
  • record all results and data generated to an agreed standard, store all data as directed and make them available to the line manager
  • take responsibility of and proactively manage zebrafish lines as agreed with the line manager in compliance with all local and national regulations and rules.
  • contribute to the production of research reports, publications and communications as requested and contribute to group meetings
  • work in a timely and organised fashion to complete pieces of work, produce reports or analyses when requested and contribute to meetings to a required standard
  • work to an appropriate level of health and safety and perform such jobs as required for effective running of the laboratory
  • engage in training and development of new skills as required for delivery of project objectives
  • work with team members and collaborators to share results and expertise as directed by the line manager

The above list of responsibilities may not be exhaustive, and the post holder will be required to undertake such tasks and responsibilities as may reasonably be expected within the scope and grading of the post.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from King's College London

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge