|Salary:||Grade 5 £27,116 - £31,406 ; Grade 7 £33,309 - £40,927|
|Placed On:||13th January 2022|
|Closes:||8th February 2022|
**Investigating Alpha 1-antitrypsin phase transition in the endoplasmic reticulum**
The Marciniak lab is based in the Cambridge Institute for Medical Research (CIMR), where we combine cell biology, biochemistry, and translational medicine to understand the role of proteotoxicity in human disease. Alpha-1-antitrypsin deficiency is a monogenic disorder that affects over 3.4 million people worldwide and is the most common genetic cause of childhood liver disease. The commonest pathogenic variant of alpha-1-antitrypsin, known as the Z allele, forms aberrant protein polymers that accumulate in the endoplasmic reticulum (ER) of hepatocytes and can cause liver cirrhosis, which accounts for 10% of deaths in these patients. A key aim of our work is to understand the molecular drivers of Z alpha-1-antitrypsin accumulation and how this promotes disease.
We recently discovered that alpha-1-antitrypsin polymers can undergo a liquid-to-solid phase transition in the ER to form a porous matrix that alters the biophysical properties of the organelle. We are now seeking a talented and enthusiastic Research Assistant or Research Associate who will be funded by the Alpha1-Foundation to use proteomics, flow cytometry, advanced live-cell imaging, and stem cell models of alpha1-antitrypsin deficiency to study the consequences of this phase transition.
Applicants for appointment as Research Assistant must possess a BSc degree or equivalent. Applicants for Research Associate should hold (or are soon to be awarded) a PhD, in a relevant discipline. The successful candidate must have experience of wet lab experimental work. Prior experience of proteomics, flow cytometry or fluorescence microscopy would be advantageous, but not essential as training will be provided. The successful applicant will join our diverse team comprised of both basic scientists and clinician scientists. We are committed to promoting an exciting, rewarding and healthy working environment and strive to support the career goals of our team members.
Fixed-term: The funds for this post are available for 2 years in the first instance.
To apply online for this vacancy and to view further information about the role, please visit:
Please quote reference SC29704 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.
The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
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