Postdoctoral Research Scientist - Gutierrez Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary 

Our group is a diverse team of scientists interested in the area of host and pathogen interactions in tuberculosis with a focus on the cell biology innate immune system and phagocytosis. To study human disease, we are developing bioengineered stem cell based cellular systems to better understand lung infection and treatment. We aim to combine iPSC technologies with organ-on-chip technologies to engineer physiologically inspired human lung-on-chips.

Project summary

In this project, we will develop cellular systems that combines CRISPR/Cas9 engineered human stem cells and three-dimensional micro-fabricated physiological environments for single cell analysis. We will use these cellular systems together with technologies developed in our group to image and quantify Mtb localisation and replication, such as live cell imaging and correlative live cell 3D- electron microscopy (CLEM). Moreover, we aim to refine these approaches to challenge the current limits of cell-based, high content imaging. The research aims to develop a new generation of iPSC-based technologies to understand human disease- and will contribute to the research funded by Wellcome leap.

Postdoctoral Research Scientists are expected to lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and guide PhD students in their research. The ability to work in a team is essential.

Key Experience 

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following: 

• PhD in stem cell biology (iPSC) or in the final stages of PhD submission
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings
• Multi modal imaging and mammalian cell biology.
• Excellent communication skills, particularly in communicating quantitative concepts to biologists
• Ability to work independently and also capable of interacting within a group
• Demonstrate continuous integrity and positivity and motivate others to do the same. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

Advert information