|Salary:||£36,382 to £42,149 Grade 8|
|Placed On:||16th May 2022|
|Closes:||26th June 2022|
An exciting opportunity for a senior research associate to work full time on an innovative 3-year programme to develop complex cell models of neurovascular disease. This will involve working with a collaborative team of researchers at Manchester Met alongside established national and international collaborators. There will be opportunities to visit the labs of our collaborators in Europe and USA to learn new techniques and transfer knowledge to Manchester Met. You will also have the opportunity to engage with multi-disciplinary scientists from cell biology to surface engineering and clinicians within the Greater Manchester region in order to develop clinically relevant models of neurovascular disease.
You will be expected to bring your own established skills within this research area in order to accelerate the programme and achieve our ambitious research objectives.
The project for this position is based within our Neuroscience Theme. The applicant will develop and characterize a 3D neurovascular model based on human iPSC-derived cell types to investigate the role of astrocytes in glymphatic fluid movement and substrate clearance in health and disease. This project links to an ongoing clinical research study investigating how sleep disturbance is associated with changes in the volumetric rate of cerebrospinal fluid flow through the brain of subjects diagnosed with mild cognitive impairment. Genotyping and proteomics data from this clinical study will inform mechanistic evaluations using the neurovascular model.
You will work within the Centre for Bioscience (https://www.mmu.ac.uk/research/research-centres/bioscience) at Manchester Met which currently has 38 Principal Investigators working across its four research themes; Cardiovascular Science, Neuroscience, Ageing & Lifelong Health and Microbiology. We benefit from recently completely refurbished laboratories, with a dedicated complex cell models suite equipped with state-of-the-art equipment including cell culture facilities, a hypoxic chamber, vascular flow platforms and real-time image analysis systems.
Our imaging facility includes a newly installed super resolution confocal microscope, calcium imaging, patch-clamping and microelectrode electrophysiology equipment whilst our genomics facility includes multiple next generation sequencing and pyrosequencing platforms. The Faculty of Science & Engineering opens its £120M new building in 2023. This will provide next generation teaching, office and conferencing space conjoined with the refurbished research labs.
The Centre for Bioscience is an exciting and dynamic environment in which to conduct cutting edge research. We are looking to recruit, support and mentor experienced, motivated Research Associates toward progression and retention as Fellows or future permanent Faculty Academics.
Qualification we require:
You must have a PhD in a neuroscience related field and post-doctoral research experience in the same or related field.
Experience of the following would be advantageous:
Evidence of Good Laboratory Practice in cell culture, excellent communication skills and an ability to thoroughly document and evaluate data is essential.
Type / Role: