Back to search results

PhD Studentship: Optimization and Validation of Portable Spectroscopic Device to Detect TBI in a Pre-clinical Animal Model

University of Birmingham - School of Chemical Engineering

Qualification Type: PhD
Location: Birmingham
Funding for: UK Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 16th May 2022
Closes: 18th July 2022

A PhD Studentship is available for a suitably qualified candidate to conduct research leading to the award of a PhD degree in the field of Chemical Engineering. The successful candidate will join the world-leading Advanced Nano-Materials, Structures and Applications (www.ANMSA.com) Group, one of the leading academic groups in the field of development of novel miniaturized diagnostic technologies. We are looking for a highly motivated, bright and enthusiastic candidate ideally with a background in or understanding of laboratory animal neuroscience and ophthalmology or fabrication, characterization and development of miniaturized device. This project is of a highly interdisciplinary nature, at the interface of microengineering, biophysics and medicine, will focus on developing new methods for improved and accurate detection and assessment of traumatic brain injury (TBI) as well as understanding, monitoring and controlling the cellular and tissue responses to therapeutic treatments. TBI is a leading cause of death worldwide. TBI is caused by sudden shock or impact to the head. This can cause mild to severe injury to the brain and needs diagnosis and treatment as soon as possible to prevent further irreversible damage. However, TBI is hard to diagnose at the point-of-injury.

We are developing a portable device that can be used to assess patients allowing rapid diagnosis and assessment of severity. We have previously shown that the device can detect TBI in animal brain tissues after the animal died. We have also developed decision support tools for the device, using artificial intelligence, to rapidly classify TBI. Whilst post-mortem assessments demonstrate feasibility, acute changes in living tissues may differ and display a much richer and more complex pattern of molecular responses.

This PhD project will focus on optimizing a prototype of spectroscopic-fundus imaging in a rat model of optic nerve crush injury and demonstrate a usable device that rapidly classifies injury-related spectral data, capable of detecting changes in TBI. Demonstration of the retinal Raman spectroscopic signature in the rat eyes after optic nerve crush and in control eyes will be established. This will test the device in-vivo for the first time to show that we can detect the same biochemical changes after injury in post-mortem tissues and examine the time course of molecular changes after injury. The animals will be imaged over time after injury to determine if the imaging system will effectively differentiate between injured and control animals during the acute, subacute, and chronic stages of neurotrauma. Endpoint histology will complement the imaging study.

The multidisciplinary nature of this project will enable developing strong collaborations and integrating scientific findings with related projects as well as building broad skills-set that will maximize the knowledge and chances in making an impact on the world’s academic and industrial stages.

The candidate should be qualified to at least first-degree level with an upper second- or first-class honors degree in an appropriate branch of Engineering or Biomedical Sciences or related fields. The studentship is fully funded covering the maintenance, College and University fees and continuation of funding is subject to annual performance review. Applications comprising a detailed CV, Cover letter, the names and addresses of two referees should be sent by email to Professor P. G. Oppenheimer: GoldberP@bham.ac.uk and Dr R. Blanch: r.j.blanch@bham.ac.uk. The successful applicant will be required subsequently to submit a standard application to the University.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Birmingham

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge