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Research Associate in Structural and Molecular Biology

University of York - Biology

Location: York
Salary: £33,309 to £40,927 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 4th July 2022
Closes: 12th August 2022
Job Ref: 10975

Department

We are looking for a full-time Postdoctoral Research Associate to join the Hill Lab based in the Department of Biology at the University of York (https://www.hill-lab.co.uk/). Our research focuses on understanding molecular mechanisms of gene expression in RNA viruses. We apply a multidisciplinary approach including X-ray crystallography, cryo-EM single-molecule biophysics and biochemical reconstitution to study ribosomal ‘recoding’ events during infection (Hill et al. Nature Communications 2021; Hill et al. Nucleic Acids Research 2021; Caliskan & Hill, Bioscience Reports 2022).

Role

This position will be focused on using cryo-EM to study programmed ribosomal frameshifting during viral genome translation, and the development of a fluorescent single-molecule reporter assay to study the kinetics of frameshifting in real-time. The successful candidate will join a Wellcome-funded collaborative project between our group, Dr Christoph Baumann and Dr Peter O’Toole. You will have access to the very latest equipment in electron cryo-microscopy and light microscopy, including a 200 kV Glacios cryo-TEM with Falcon IV detector, Zeiss Elyra 7 super-resolution microscope and bespoke TIRF microscope. Expert training and support will be available through the world-leading Bioscience Technology Facility and the York Structural Biology Laboratory. You will drive independent projects, but also work closely with other lab members and assist in the identification and development of potential areas of research and the development of proposals. You will be expected to write up research results for dissemination through publications, seminar and conference presentations and will be encouraged to participate in public engagement and science outreach activities. Opportunities for mentorship and additional collaborations will be available and encouraged.

The post is full-time, fixed term for 3 years, and salary will be in the range £33,309 - £40,927 a year.

Skills, Experience & Qualifications needed

  • PhD or equivalent research experience in molecular biology, cell biology, tructural biology or biophysics
  • Demonstrable research experience, evidenced by publications in peer-reviewed journals, and having presented your work at national and/or international conferences
  • Specific expertise in molecular biology, including protein expression and purification
  • Experience of fluorescence microscopy, single-molecule imaging or structure determination using cryo-EM would be advantageous
  • Knowledge of RNA biology, ribosome biology or viral gene expression would be advantageous.

Interview date: to be confirmed

For informal enquiries: please contact Dr. Chris Hill via email chris.hill@york.ac.uk

The University strives to be diverse and inclusive – a place where we can ALL be ourselves.

We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.

We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff. #EqualityatYork

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