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Postdoc single-cell DNA sequencing and mathematical analysis of pre-cancerous tissue (Fixed Term)

University of Cambridge - Department of Oncology

Location: Cambridge
Salary: £33,309 to £40,927
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 5th August 2022
Closes: 5th September 2022
Job Ref: RD32565

Overview. The Blundell lab at the University of Cambridge is seeking a candidate for a postdoctoral position generating single-cell DNA sequencing data from isolated pre-leukemic stem cells and mathematical analysis of the resulting data. This is part of a UKRI Future Leaders Fellowship project on blood cancer risk prediction. The overarching aim is about understanding how aggressive blood cancers evolve from healthy tissue. We are an interdisciplinary group focused on applying mathematical, evolutionary and statistical approaches to understand the behaviour of mutant clones that expand in our tissues as we age and how these impact cancer risk. We generate and analyse DNA sequencing data sets from clinical samples to build predictive models of cancer risk.

Project. The central aim of the project is to use representation of leukaemic mutations in healthy stem cells to better understand the evolutionary process dictating how leukaemia evolves from healthy blood stem cells. The project will involve flow cytometry of bone marrow aspirates taken from individuals diagnosed with acute myeloid leukaemia and use of the Tapestri single-cell DNA sequencing platform (Mission Bio) to build phylogenetic trees from the pre-leukemic stem cell compartment. There is a substantial modelling component to the project whereby we hope to use mathematical models of AML evolution to understand what the structure of these phylogenetic trees can tell us about the evolutionary process leading to AML.

Candidate. Candidates should have(or be close to finishing) a PhD in genomics, quantitative biology, physics or mathematics, an excellent research record and an interest in biological / clinical applications of genomics and maths. Experience with flow cytometry, genomic datasets and experience programming in Python are essential.

Lab and environment. The Blundell lab is part of the Early Cancer Institute in the Department of Oncology at the University of Cambridge. We are embedded in the CRUK Cambridge Centre. Situated on Cambridge Biomedical Research Campus, with close ties to Addenbrooke's Hospital and a host of biotech companies, our location affords our members access to human tissue samples, state of the art sequencing facilities, and the opportunity to forge collaborations with world class physicists, engineers, biologists and clinicians in Cambridge. More information on the lab can be found at www.blundelllab.com

Enquiries. Informal enquiries should be directed to Jamie Blundell via e-mail: jrb75@cam.ac.uk.

Fixed-term: The funds for this post are available for 1 year in the first instance.

To apply online for this vacancy and to view further information about the role, please visit:

http://www.jobs.cam.ac.uk/job/36347.

Interview Date: TBC

Please include details of your referees, including e-mail address and phone number, one of which must be your most recent line manager.

Please quote reference RD32565 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

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