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Research Technician

Imperial College London

Location: London
Salary: £31,773 to £34,680
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 23rd September 2022
Closes: 18th October 2022
Job Ref: MED03397
 

Job Summary

The advertised position will be working in Dr Mohamed Shamji’s research group within National Heart and Lung Institute (NHLI), Inflammation Repair and Development, Allergy and Clinical Immunology, Faculty of Medicine. Allergic rhinitis (AR) affects up to 40% of the global population and pose a huge economic and social burden. Whilst AR can be controlled temporarily with symptom-reliever such as anti-histamines and corticosteroids, a small proportion of sufferers do not respond to treatment. Allergen-specific immunotherapy (AIT) is indicated in these patients. Despite their efficacy, AIT is associated with long-term treatment regimen which is associated with low patient compliance and occasional severe reactions.

The post-holder will be involved in a very exciting and fast-paced clinical trial study, in collaboration with Revolo Biotherapeutics, to investigate the immunomodulatory properties of a novel peptide that can be used the treatment of allergic rhinitis in AIT. The post-holder will be involved in the collection of clinical samples at multiple timepoints during the clinical trial study and will be involved in performing all relevant immunological and cellular assays to allow assessment of the efficacy of treatment. This will include biobanking of peripheral blood mononuclear cells (PBMCs), basophil activation and histamine release assessment using flow cytometry and in vitro cell culture assays. Flexible attitude towards work is hugely required in this role due to the nature of clinical sample timepoints for the study. The overarching objective is to define the mechanism of action of the novel AIT product and its efficacy.   

Duties and responsibilities 

  • To support Dr Shamji’s research at Imperial college London
  • To perform biobanking of PBMCs from whole blood material
  • To perform flow cytometry, magnetic cell isolation, cell culture, ELISA, on clinical blood samples obtained from patient sample materials
  • To organise and liaise with clinical team to ensure prompt collection of patient sample materials
  • To contribute to the supervision and training of undergraduate and master’s students in the lab
  • To continually update knowledge and understanding in the field or specialism and develop skills
  • To assist with the analysis of data
  • To ensure the validity and reliability of data at all times
  • To maintain accurate and complete records of clinical samples
  • To assist with the writing of reports to research sponsors
  • To present findings to colleagues
  • To provide advice to other staff and students
  • To assist with the publication of findings
  • To attend relevant workshops and conferences as necessary
  • To develop contacts within the College and the wider community
  • To promote the reputation of the Group, the Department and the College

Essential requirements 

  • Hold a Master’s degree (MSc or MRes) in life sciences or equivalent relevant laboratory based experience
  • Experience in laboratory-based research
  • Practical experience with working with peripheral blood
  • Experience in collection, preparation, processing and/or storage of samples
  • Experience with data analysis for flow cytometry

Further Information

This is a post for 2 Full Time and Fixed Term posts for a length of 6 months based at the South Kensington Campus, London.

Closing date: 18 Oct 22

To apply, visit www.imperial.ac.uk/jobs and search by the job reference MED03397

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