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Research Associate in Developmental Biology

Imperial College London - Department of Life Sciences - Faculty of Natural Sciences

Location: London
Salary: £43,093 to £46,734 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 29th September 2022
Closes: 27th October 2022
Job Ref: NAT01280
 

Location: South Kensington Campus

Job Summary

What are the key epigenetic mechanisms that keep neural stem cell genes off in neurons and prevent dedifferentiation? And how do these change as an organism ages?

To answer these fundamental questions, you will apply improved epigenome editing tools (for multiplexed and multi-modal epigenome editing), together with cell type specific profiling of protein-DNA interactions and histone marks (using Targeted DamID). These will be applied in vivo in Drosophila. Furthermore, on this project, you will be closely collaborating with the van den Ameele lab (University of Cambridge) who will be performing parallel experiments using mice, whilst also examining how metabolism can impact these epigenetic processes.

Why should you apply for this Research Associate position? You will learn and apply cutting-edge techniques in this project, of which the findings will have important implications for the fields of developmental biology, ageing and regenerative medicine. You will be based on the 4th floor of the Sir Ernst Chain Building, integrated with other labs studying the nervous system, and be part of a vibrant and friendly Drosophila research community.

The position offers the diverse and highly interactive research environment of a world-leading University.

Lab website: https://www.southall-lab.info/

Some relevant publications:

Southall et al., 2014, Dev Cell; Southall et al., 2013, Dev Cell; Aughey et al., 2018 eLife;

Hassan et al., 2020, eLife 

Duties and responsibilities

In your role, you will take initiatives in the planning of research, identify (and develop) suitable techniques for the collection and analysis of data. You will disseminate your work through talks at conferences and writing (and publishing) scientific articles. You will also have the opportunity to supervise and manage junior researcher/students working in the lab. Furthering your training, you will contribute to bids for research grants and participate and initiate collaborations with other scientists/labs. As a member of our research group, you will participate in Group research meetings and internal seminars.

Essential requirements

You must have, or be near completion of, a PhD (or equivalent) in Biological Sciences. Preference will be given to those with considerable work experience in molecular biology, genome wide profiling techniques (e.g. protein-DNA interactions or expression profiling), and confocal microscopy. If you have previous experience with Drosophila that would be preferred but it is not essential. Due to the large quantity of genomic data that will be generated, familiarity with bioinformatics and programming would be advantageous.

Further Information

This is a full time, fixed term position for up to 36 months. You will be expected to start in February 2023 and will be based at South Kensington Campus.

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £38,194 - £41,388 per annum.

Candidates need to complete an online application.

Should you require any further details on the role please contact: Tony Southall – t.southall@imperial.ac.uk.

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