Back to search results

PhD Studentship: Demystifying the Activation Mechanism of Glucagon-Like Peptide Receptor 1

Coventry University - Centre for Sport, Exercise and Life Sciences

Qualification Type: PhD
Location: Coventry
Funding for: UK Students, EU Students, International Students
Funding amount: Fully Funded with Stipend
Hours: Full Time
Placed On: 20th December 2022
Closes: 6th May 2023

Coventry University (CU) is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship.

The glucagon-like peptide receptor (GLP-1R) is a validated target for type 2 diabetes (T2D). The structure of GLP-1R and how new potential T2D oral drugs bind are well known. However, we have no information about the dynamic process leading to drug:receptor complex formation.  

The project aims to develop and apply state-of-the-art computational modelling via advanced molecular dynamic simulations to understand the complete binding mechanism of the human hormone GLP-1 and drug-like molecules recently discovered. This project is composed of two parallel and independent work strands. One line of research will focus on the endogenous agonists, i.e. GLP-1, while the other will address recently discovered non-peptidic agonists and their binding mechanism. This in-silico investigation will deliver, for the first time, a complete GLP-1R binding model, paving the way to the rational design of a new generation of medicines against T2D. 

The project will advantage from collaborations with world-leading scientists from Monash University (AUS) and Imperial College (UK). 

Bibliography 

  • Activation of the GLP-1 Receptor by a Non-Peptidic Agonist. Nature 2020, 577, 432–436
  • Structure and Dynamics of the Active Gs-Coupled Human Secretin Receptor. Nat. Commun. 2020, 11, 4137.
  • Structural and Functional Diversity among Agonist-Bound States of the GLP-1 Receptor. Nat. Chem. Biol. 2021, 18, 256–263
  • Dynamics of GLP-1R Peptide Agonist Engagement Are Correlated with Kinetics of G Protein Activation. Nat. Commun. 2022, 13, 92

Entry criteria for applicants to PhD  

  • A bachelor’s (honours) degree in a relevant discipline/subject area with a minimum classification of 2:1 and a minimum mark of 60% in the project element (or equivalent), or an equivalent award from an overseas institution.
    PLUS  
  • the potential to engage in innovative research and to complete the PhD within 3.5 years
  • An adequate proficiency in English must be demonstrated by applicants whose first language is not English.  The general requirement is a minimum overall IELTS Academic score of 7.0 with a minimum of 6.5 in each of the four sections, or the TOEFL iBT test with a minimum overall score of 95 with a minimum of 21 in each of the four sections.

For further details please visit:  https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/research-entry-criteria/ 

https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/ 

To find out more about the project please contact Dr Giuseppe Deganutti (ad5288@coventry.ac.uk)

To apply on line please visit: Home Page | PGR+ Application (coventry.ac.uk) 

The PGR+ Link for this project is 

Details of all available research opportunities at Coventry University can be found via

https://www.coventry.ac.uk/research/research-opportunities/

All applications require full supporting documentation, and a covering letter – plus one of the following (please select one option)

For pre-determined (named) projects an up-to 2000-word supporting statement is required showing how the applicant’s expertise and interests are relevant to the project. 

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from Coventry University

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge