Qualification Type: | PhD |
---|---|
Location: | Coventry |
Funding for: | UK Students, EU Students, International Students |
Funding amount: | Fully Funded with Stipend |
Hours: | Full Time |
Placed On: | 20th December 2022 |
---|---|
Closes: | 6th May 2023 |
Coventry University (CU) is inviting applications from suitably-qualified graduates for a fully-funded PhD studentship.
The glucagon-like peptide receptor (GLP-1R) is a validated target for type 2 diabetes (T2D). The structure of GLP-1R and how new potential T2D oral drugs bind are well known. However, we have no information about the dynamic process leading to drug:receptor complex formation.
The project aims to develop and apply state-of-the-art computational modelling via advanced molecular dynamic simulations to understand the complete binding mechanism of the human hormone GLP-1 and drug-like molecules recently discovered. This project is composed of two parallel and independent work strands. One line of research will focus on the endogenous agonists, i.e. GLP-1, while the other will address recently discovered non-peptidic agonists and their binding mechanism. This in-silico investigation will deliver, for the first time, a complete GLP-1R binding model, paving the way to the rational design of a new generation of medicines against T2D.
The project will advantage from collaborations with world-leading scientists from Monash University (AUS) and Imperial College (UK).
Bibliography
Entry criteria for applicants to PhD
For further details please visit: https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/research-entry-criteria/
https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/
To find out more about the project please contact Dr Giuseppe Deganutti (ad5288@coventry.ac.uk)
To apply on line please visit: Home Page | PGR+ Application (coventry.ac.uk)
The PGR+ Link for this project is
Details of all available research opportunities at Coventry University can be found via
https://www.coventry.ac.uk/research/research-opportunities/
All applications require full supporting documentation, and a covering letter – plus one of the following (please select one option)
For pre-determined (named) projects an up-to 2000-word supporting statement is required showing how the applicant’s expertise and interests are relevant to the project.
Type / Role:
Subject Area(s):
Location(s):