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PhD Studentship: Developing Drugs from Natural Product Scaffolds

University of Sussex - Chemistry

Qualification Type: PhD
Location: Falmer
Funding for: UK Students
Funding amount: Home tuition fees and stipend at standard UKRI rates
Hours: Full Time
Placed On: 26th January 2023
Closes: 31st March 2023
 

A PhD studentship (3.5 years) is available from September 2023 under the supervision of Prof John Spencer and Dr Barnaby Greenland, Chemistry department, School of Life Sciences.

Deadline: 31st March 2023

Project Title: Developing Drugs from Natural Product Scaffolds

Brief Description of the Project:

We wish to synthesise druglike entities starting from a natural product scaffold that we can acquire in gram quantities. This will involve chemical synthesis, late-stage functionalisation, atom economical catalysis, mechanochemistry, use of preparative HPLC, microwaves, flow chemistry.

The student will be trained in an industry-standard laboratory, learn about parallel synthesis and library generation and fundamentals of medicinal chemistry (through taught classes and, also, through the PhD laboratory project) such as bioisosteres, conformational restriction, use of solubilising groups, working in a team comprising several industrially-experience postdoctoral chemists and biologists. There is also a possibility to develop druglike entities and learn about Home Office Licensing and GMP.

There will be an opportunity, as part of the training programme, to spend time (usually 3 months) in the industrial partner’s laboratories.

This EPSRC iCASE position covers Home tuition fees and a stipend at standard UKRI rates for 3.5 years.

How to apply:

Please submit a formal application using the online admissions portal attaching a CV, degree transcripts and certificates, personal statement, and two academic references. A research proposal is not required.

On the application system select Programme of Study – PhD Chemistry. Please state the project title under funding obtained and the supervisor’s name where required.

Ideal candidates will have a strong background in organic chemistry. Candidates should have or expect to obtain a minimum 2:1 undergraduate degree. An MSc degree will be advantageous. Your qualification should be in chemistry or a related subject area. You may also be considered for the position if you have other professional qualifications or experience of equivalent standing.

Candidates for whom English is not their first language will require an IELTS (or equivalent) score of 6.5 overall, with not less than 6.0 in any section.

For enquiries about the application process, contact Emma Chorley: lifesci-rec@sussex.ac.uk

For enquiries about the project, contact the supervisor: j.spencer@sussex.ac.uk;  b.w.greenland@sussex.ac.uk

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