Project Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

An exciting opportunity to be part of a new collaboration between the Crick Chemical Biology Science and Technology Platform and the laboratories of Dr. Louise Walport and Prof. Ed Tate, based jointly at the Crick and Imperial College London, and working closely with Prof. Mike Waring at the University of Newcastle 

We are seeking a motivated and enthusiastic synthetic chemist or chemical biologist to lead a project involving design, synthesis and screening of new small molecule DELs, hit validation and further characterisation of mode of action. The successful candidate will be responsible for leading and conducting their own research as part of a small team, working closely with other members of the Chemical Biology STP and the Walport and Tate groups. Your work will involve application of a wide range of techniques in synthetic chemistry, drug discovery, chemical biology, protein biochemistry and biophysics. We are therefore seeking someone with experience in a selection of these approaches and a willingness to learn others, as dictated by the project.

Key Responsibilities

• Design, synthesis and screening of new small molecule DNA Encoded Libraries
• Design and execution of synthetic routes for off-DNA synthesis and follow-up of screening hits
• Hit characterisation using standard biophysical and biochemical approaches
• Leading, conducting and recording research at the forefront of modern drug discovery 
• Collaboration with other members of the Chemical Biology STP, Walport, Tate and external partner labs 
• Reporting to regular lab meetings and project team meetings
• Producing accurate report-ready data and lead or collaborate in the preparation of written progress reports and publications/patents as required
• Engaging in oversight of safe working and lab management alongside your colleagues 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 02.03.2023
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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