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Senior Application Experts for in situ Structural Biology (2 posts) (10270)

Rosalind Franklin Institute

Location: Harwell
Salary: £42,500 to £50,500 pa depending on experience
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 20th March 2023
Closes: 16th April 2023
Job Ref: 10270

The Rosalind Franklin Institute is a national Research Centre, funded by the UK government through UK Research and Innovation (UKRI), dedicated to bringing about transformative changes in life science through interdisciplinary research and technology. The Electrifying Science grants from the Wellcome Trust and the Amplus project funded by EPSRC both aim to develop new instrumentation for life science. In addition to state-of-the-art instruments, the institute houses and develops new technology, and the focus of this role is to disseminate these applications and developments via training and publication. The Franklin is working closely with microscope manufacturers (ie. ThermoFisher Scientific, Jeol), national facilities (ie. CCP-EM, eBiC) and houses an internal Artificial Intelligence and Informatics theme. The Franklin is seeking to recruit two senior Application Experts within the Structural Biology theme of Rosalind Franklin Institute. The roles will be in in situ structural biology using state-of-the-art pFIB and TEM machines. One role will focus on novel approaches to correlate pFIB / SEM / fluorescent images of samples. The other role will focus on correlations between different image modalities (SEM, fluorescence, STEM…) and TEM tomographic subvolumes. In addition to microscopy instrumentation both posts will drive image acquisition, correlation and post-processing analysis. As application experts you will lead on scientific challenges of imaging diseases in tissues, atomic pathology.  The candidates will work closely with each other and the development teams (hardware & software, industry and in-house) to provide user requirements/specifications and feedback throughout the development cycle.

The two roles will establish and map out at atomic level diseases in tissue or organoid / cell models. To do this one post will establish new workflows to take biological samples though pFIB correlative imaging of tissue. The other post will focus on high resolution correlative techniques to find the protein of interest in cryo-ET data. Each post will identify the opportunities for further development. In addition to our established collaboration with clinical and industrial researchers, there is an opportunity for each post to develop and lead your own project. Your excellent communication skills will support the dissemination of the newly developed techniques and/or protocols via training, internal communication, publication, and conferences.

The key objective is to deliver a factor of ten change in in situ structural biology.

Before submitting your application, please ensure you read the Job Information Pack for full details of this role by clicking on the 'Apply' button above

About us: The Rosalind Franklin Institute is a new national Research Centre, funded by the UK government through UK Research and Innovation, dedicated to bringing about transformative changes in life science through interdisciplinary research and technology.

Location: The Franklin is based in Harwell Campus, UK’s innovation hub and well-established as one of the leading science and innovation campuses in Europe. 

At the Rosalind Franklin Institute we welcome applications from all around the world!

Closing date: Sunday 16th April 2023

Period of appointment: 3 years fixed term contract

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