Back to search results

PhD Studentship: Visible-light-mediated Functionalisation of Amino Acids, Peptides, and Proteins

University of Nottingham - Chemistry

Qualification Type: PhD
Location: Nottingham
Funding for: UK Students
Funding amount: A tax-free stipend at the standard UKRI rate (currently £17,668 per year).
Hours: Full Time
Placed On: 20th March 2023
Closes: 20th June 2023
Reference: SCI2173

Location: UK Other

Closing Date: Tuesday 20 June 2023

Dr Nicholas Mitchell (nicholas.mitchell@nottingham.ac.uk)

Applications accepted all year round.

Fully-funded PhD project (UK Students Only)

About the project

A PhD studentship funded by the Leverhulme Trust in synthetic chemistry/peptide chemistry/photochemistry is available in the research group of Dr Nicholas Mitchell based in the School of Chemistry, University of Nottingham (https://nicholasjmitchell.wixsite.com/themitchellgroup).

Start date: 2 October 2023. Application deadline: The position will remain open until a suitable candidate is found.

Background

The diverse array of chemical functionality displayed by the 20 canonical amino acids presents both challenges and opportunities for the development of peptide and protein conjugation chemistry. Techniques that enable the residue-specific modification of polypeptides provide tools to facilitate the study and manipulation of biological systems, and the preparation of therapeutic/diagnostic agents. 

Previous work in our group concerns the exploration of operationally simple photochemical methods to install groups of interest into peptide and protein scaffolds (Angew. Chem. Int. Ed. 2020, 59, 23659-23667; Angew. Chem. Int. Ed., 2022, 61, e202110223; Chem. Eur. J., 2023, e202202503). These reports include examples of stereoretentive C(sp3)-C(sp3) bond forming photochemistry which enables the installation of protein post-translational modifications (PTMs). We wish to further extend the reach of this synthetic platform to explore the chemically modified proteome, and develop drug conjugates and peptide inhibitors for disease-relevant protein-protein interactions (PPIs).

Project Aim

This project will involve the development of new photochemical methods to synthesise non-canonical amino acids, and site-selectively modify peptides and proteins. The candidate will further extend the scope of our desulfurative strategy as well as developing new avenues based on the natural chemical functionality of the proteome.

Entry requirements

Applications are invited from UK home students (due to funding restrictions) with an interest in organic synthesis, photochemistry, and chemical biology. Applicants should have, or expect to achieve, at least a 2:1 Honours Masters degree (or BSc with substantial research experience) in Chemistry, Natural Science specialising in chemistry, or a similar degree. 

To apply please send your CV (max 2 pages) and a cover letter to nicholas.mitchell@nottingham.ac.uk

Funding Notes

This PhD studentship is fully-funded for 36 months by the Leverhulme Trust starting in October 2023. This funding covers the payment of tuition fees at the UK/home rate and gives you a tax-free stipend at the standard UKRI rate (currently £17,668 per year). Due to funding restrictions this position can unfortunately not be offered to EU or international students.

Please contact Dr Nicholas Mitchell (nicholas.mitchell@nottingham.ac.uk) for further information.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Nottingham

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge