PhD Studentship: Structural and Computational Studies of the IRF4-DNA regulatory interactions in Multiple Myeloma

PROJECT TITLE: Structural and Computational Studies of the IRF4-DNA regulatory interactions in Multiple Myeloma

BRIEF DESCRIPTION OF THE PROJECT:

We are seeking a motivated and experienced PhD student to join our team in the Department of Biochemistry at the University of Sussex. The studentship will focus on the structural and functional characterization of transcription factors involved in  Multiple Myeloma.

Multiple Myeloma is an aggressive cancer of plasma cells, which are a type of white blood cell. The disease is characterized by the overproduction of monoclonal antibodies, which are proteins that are produced by a single cell type. Multiple Myeloma is incurable and new treatments are urgently required.

The student will use a combination of biochemical, biophysical, and structural biology techniques to study the interaction between proteins and DNA. The student will also use computational modelling to study the impact of DNA interactions on the expression of target genes.

The successful candidate will have a strong background in molecular biology and biochemistry and experience in protein expression and purification is essential. Experience in structural biology and computational modelling is desirable but not necessary. The student will be able to work independently and as part of a team.

How to apply:

Please submit a formal application using the online admissions portal attaching a CV, degree transcripts and certificates, personal statement, and two academic references. A research proposal is not required.

On the application system select Programme of Study – PhD Biochemistry. Please state the project title under funding obtained and the supervisor’s name where required.

Candidates should have or expect to obtain a minimum 2:1 undergraduate degree. An MSc degree will be advantageous. Your qualification should be in Biochemistry or a related subject area. You may also be considered for the position if you have other professional qualifications or experience of equivalent standing.

Candidates for whom English is not their first language will require an IELTS score of 6.5 overall, with not less than 6.0 in any section - English language requirements

The University is committed to equality and valuing diversity, and applications are particularly welcomed from women and black and minority ethnic candidates, who are under-represented in Science, Technology, Engineering, Medicine and Mathematics (STEMM) at Sussex.

For enquiries about the application process, please email Emma Chorley: lifesci-rec@sussex.ac.uk

For enquiries about the project, please contact the supervisor: erika.mancini@sussex.ac.uk

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