Research Fellow in Structural Biology of KRAS activation and inhibition

Full time starting salary is normally in the range £34,980 to £44,263 with potential progression once in post to £46,974 

Grade 7

Full Time, Fixed Term Contract up to September 2026

Job Summary

Our international group of highly motivated and interdisciplinary structural biologists is expanding. We are looking for a research fellow fascinated by molecular mechanisms. You will investigate the structural basis for the dysregulation of KRAS activation in cancer. The project is a collaboration with a signalling network lab and ultimately aims to develop inhibitors of hyperactive KRAS mutants. We offer unique access to first-class instrumentation for structural biology. At the National Centre for Biomolecular NMR Spectroscopy in Birmingham (HWB-NMR), we host the best biomolecular NMR equipment available in the UK, comprising 1000, 900 and 800 MHz spectrometers equipped with cryoprobes and MAS probes for both solution- and solid-state NMR, as well as an incoming 1.2 GHz spectrometer expected in 2025. At the Midlands Regional Cryo Electron Microscope Facility in Leicester, you will have access to a 300-kV Titan Krios G3 cryo-electron microscope with a direct electron-detecting camera. We also have access to the synchrotron at DIAMOND for small-angle scattering, X-ray crystallography and other X-ray based techniques. Fully equipped biochemistry and molecular biology laboratories, as well as extensive equipment for in cellulo work and light microscopy are available. Our vibrant interdisciplinary research environment will provide you with unique career development opportunities.

Our globally-operating research group is embedded in a lively community of world-renowned scientists in the fields of genome biology, cancer research and microbiology. We believe in interdisciplinarity and we strive to integrate structural biology with functional studies in cells and whole organisms, as well as with drug design and molecular engineering.

Main Duties

• Project planning: set milestones and deliverables.
• Plan and perform experiments and data analysis.
• Troubleshoot experiments; develop or adapt techniques, models and methods.
• Interpret the data, periodically evaluate the research plan and adjust as needed.
• Develop strategies towards achieving project success.
• Critically analyse results in the broader context.

Personal Specification

• PhD (or near to completion) in Biophysics/Biochemistry/Chemistry/Chemical Biology/Structural Biology or related areas. Or equivalent qualifications.
• Genuine interest in molecular mechanisms.
• Excellent analytical skills.
• Proven experience in structural biology, both in data acquisition and analysis.
• Track record of working successfully in a biochemical laboratory.

For further information please contact Professor Teresa Carlomagno, T.Carlomagno@bham.ac.uk 

To download the full job description and details of this position and submit an electronic application online please click on the 'Apply' button above.

Valuing excellence, sustaining investment 

We value diversity and inclusion at the University of Birmingham and welcome applications from all sections of the community and are open to discussions around all forms of flexible working. 

Advert information