Postdoctoral Research Associate in CAR T-cell PET Imaging

Location: St Thomas’ Campus

Contact details: Dr Ran Yan. ran.yan@kcl.ac.uk

Job description

We are seeking a proactive and collaborative Chimeric Antigen Receptor (CAR) T-cell biologist to join Dr Yan’s group in the School of Biomedical Engineering & Imaging Sciences, King’s College London. We are a dynamic radiochemistry and biology team with access to cutting-edge instruments for preclinical nuclear imaging. You will develop a new generation of CAR T-cell PET imaging reagent to provide early insight to the safety and efficacy of the infused cell products.

In collaboration with CAR T-cell scientists, Dr John Maher and James Arnold from KCL and radiochemist, Prof Erik Årstad from UCL, the successful candidate will evaluate novel PET tracers to the detection of CAR T-cell’s biodistribution and behaviour in preclinical mouse cancer models. The project involves the generation of cancer targeting CAR T-cells, in vitro biological evaluation of CAR T-cell specific radiotracers, establishing tumour xenograft models, and PET imaging of CAR T-cells in tumour xenograft models with newly developed PET tracers. The ultimate goal is to develop a generic long-term CAR T-cell PET imaging strategy to enable clinicians to determine the real-time in vivo biodistribution of the CAR T-cells allowing prediction of therapeutic efficacy and potential off-target toxicity of therapeutic cells at earlier stages of their development.

We expect the successful candidate to hold a PhD degree and research experience in CAR T-cell biology and have a strong track record of research achievements. Experience with small animal imaging is desirable. Experience in handling of radioactivity is preferred.

This post will be offered on a fixed-term contract for up to three years (latest end date 30 November 2026).

This is a full-time post - 100% full time equivalent.

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