Back to search results

PhD Studentship: Modelling the RASopathy Gene Networks to Predict Clinical Phenotypes.

UCL - Department of Medical Physics and Biomedical Engineering

Qualification Type: PhD
Location: London
Funding for: UK Students
Funding amount: See advert
Hours: Full Time
Placed On: 30th October 2023
Closes: 31st January 2024
Reference: 23032

Primary Supervisor: Ben Hall

Secondary supervisor: Sara Hillman

Introduction:

A 4 year funded PhD studentship is available in the Computational Biology of Cancer and Precancer group (https://www.hall-lab.com/), based at UCL’s Department of Medical Physics and Biomedical Engineering (https://www.ucl.ac.uk/medical-physics-biomedical-engineering/ucl-medical-physics-and-biomedical-engineering). Funding will be at least the UCL minimum. Stipend details can be found here.

Project Background: 

RASopathies are associated with severe conditions that present in utero. These present dangers to both child and mother, and improved prediction of specific conditions such as hydrops fetalis would enabled enhanced monitoring and early intervention for high risk individuals, and reduce costs for monitoring of lower risk individuals. However, siblings carrying the same variants do not necessarily present the with the same conditions. Over the course of the PhD you will develop models that resolve this variability in presentation through the use of network models that consider variants in other pathway members that might compensate for overactive genes and protect the individual. These models will be used to power AI approaches for clinical decision making, through a web based interface designed for clinicians.

Research aims: 

Understand the molecular interactions that determine the clinical presentation of RASopathies. This will be achieved through the development of executable models, analysis of databases of gene interaction data, and analysis of patient data.

Application Details

Person specification & requirements:

Experience in computational biology is extremely beneficial. Alternatively demonstratable interest in computational biology and high levels of achievement in either physical/mathematical sciences or life sciences. Excellent communication and team working skills required.

How to apply:

Please complete the following steps to apply.

Please quote Project Code: 23032 in the email subject line.

  • Make a formal application to via the UCL application portal accessed via the 'Apply' button. Please select the programme code Medical Physics and enter Project Code 23032 under ‘Name of Award 1’

Funding

A full studentship is available for home fee payers.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge