Back to search results

PhD Studentship: GPU-Enhanced Ptychography Integration in Cryo-EM Biological 3D Imaging Framework

University of Warwick - Centre for Doctoral Training in the Modelling of Heterogeneous Materials (HetSys), Department of Physics

Qualification Type: PhD
Location: Coventry
Funding for: UK Students, EU Students, International Students
Funding amount: Fully funded
Hours: Full Time
Placed On: 23rd November 2023
Closes: 25th January 2024
Reference: hp2024-02

Supervisors:

Supervisors: Peng Wang (Physics)

Summary:

The project aims to enhance Single Particle Analysis (SPA) software, a vital 3D imaging tool in structural biology, by integrating GPU-enhanced ptychography, an advanced computational microscopy technique, into a worldwide SPA framework. Traditional SPA techniques face limitations in resolving small and complex biological macromolecules. By incorporating ptychography, known for its high phase-sensitivity and applicability in low-dose data scenarios, researchers can achieve higher resolution in cryo-electron microscopy. This integration extends the utility of SPA, allowing researchers to work with diverse imaging modalities, significantly elevate data quality, and push the boundaries of resolution. Through international collaboration with leading experts and cutting-edge resources, we aim to advance structural biology, providing the potential for more precise macromolecular reconstructions and overcoming current challenges.

Single Particle Analysis (SPA) software is a critical tool in the field of structural biology, especially for cryo-electron microscopy (cryo-EM). It plays a pivotal role in extracting structural information from biological macromolecules, enabling the generation of high-resolution 3D reconstructions. However, traditional SPA techniques have primarily relied on conventional transmission electron microscopy (TEM) imaging at high defocus. The low contrast and signal-to-noise ratio in defocused TEM images make it particularly challenging to achieve atomic-level resolution for small, heterogeneous and/or flexible molecules or complexes. Ptychography is an emerging computational microscopy technique for acquiring images with resolution beyond the limits imposed by lenses, which has been applied to high resolution x-ray imaging. Due to its high phase-sensitivity, robustness to low electron dose data and the recovery of the sample wavefunction, it represents a potentially disruptive change in the rapidly growing field of cryo-EM.

The HetSys' training programme is designed to enable students to become high-quality computational scientists who are comfortable working in interdisciplinary environments, have excellent communication skills, and well prepared for a wide range of future careers in areas where there is demonstrable need.

https://warwick.ac.uk/fac/sci/hetsys/themes/projectopportunities/hp2024-02/

To apply, please click on the 'Apply' button above.

Awards for both UK residents and international applicants pay a stipend to cover maintenance as well as paying the university fees and a research training support. The stipend is at the standard UKRI rate.

For more details visit: https://warwick.ac.uk/fac/sci/hetsys/apply/funding/

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Warwick

Show all PhDs for this organisation …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge