Back to search results

PhD Studentship: Neurodevelopmental Functions of the Histone lysine Demethylase KDM5B, Neuroscience, Epigenetics

University of Exeter

Qualification Type: PhD
Location: Exeter
Funding for: UK Students, EU Students, International Students
Funding amount: £18,622 per year tax-free
Hours: Full Time
Placed On: 24th November 2023
Closes: 28th February 2024
Reference: 5027

Project Description: 

Variants in genes encoding chromatin modifying and interacting proteins are frequent causes of neurodevelopmental disorders. This PhD project will focus on KDM5B, which encodes a histone lysine demethylase. KDM5B loss of function variants are associated with intellectual disability, autism spectrum disorders and cognitive ability in the general population. Using a combination of gene targeting and acute knock-down approaches, we have defined autism-like and learning and memory phenotypes in KDM5B-deficient mouse models.

The over-all aim of this project is to perform an in-depth analysis of the cellular and molecular mechanisms affected by KDM5B deficiency in the context of these behavioural phenotypes and to test whether targeting these mechanisms can restore normal function.

Specific objectives:

  1. To use a combination of single cell genomics, immunostaining and conditional gene deletion approaches to identify the brain regions and cell types affected by KDM5B deficiency.
  2. To use acute and in vivo electrophysiological approaches to define synaptic and circuit abnormalities in KDM5B-deficient mouse models.
  3. To use genetic and pharmacological approaches to target and identify the mechanisms responsible for neurodevelopmental phenotypes that can be targeted for therapeutic benefit.      

This award provides annual funding to cover Home tuition fees and a tax-free stipend. For students who pay Home tuition fees the award will cover the tuition fees in full, plus at least £18,622 per year tax-free stipend.  Students who pay international tuition fees are eligible to apply, but should note that the award will only provide payment for part of the international tuition fee and no stipend.  

International applicants need to be aware that you will have to cover the cost of your student visa, healthcare surcharge and other costs of moving to the UK to do a PhD. 

The conditions for eligibility of home fees status are complex and you will need to seek advice if you have moved to or from the UK (or Republic of Ireland) within the past 3 years or have applied for settled status under the EU Settlement Scheme.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Exeter

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge