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PhD Studentship in Native Mass Spectrometry for the Discovery of New Anticancer Agents

University of Nottingham - Science

Qualification Type: PhD
Location: Nottingham
Funding for: UK Students, EU Students, International Students
Funding amount: £18,622 per annum, for 2023
Hours: Full Time
Placed On: 24th November 2023
Closes: 16th January 2024
Reference: SCI240

Subject area      (BBSRC Doctoral Training Partnership, Researcher Academy)

UoN Supervisor names  Neil Oldham

Native mass spectrometry for the discovery of new anticancer agents

A 4-year fully funded BBSRC PhD CASE studentship is available at the University of Nottingham in collaboration with Erebagen Ltd to screen engineered bacterial natural product libraries for anti-cancer activity using native mass spectrometry. This exciting project is supervised by Prof Neil Oldham and Dr Luisa Ciano, from the School of Chemistry, and Dr Doug Roberts and Prof Greg Challis from Erebagen. It will provide training in biosynthetic engineering using state-of-the-art facilities as well as development of a mass spectrometry-based assay for detection of binding to the target protein, the human elongation factor eEF1A. This will be followed by structural characterisation of hit compounds, initially by coupled tandem mass spectrometry, and then complementary spectroscopic techniques.

If you are a motivated and passionate individual with a background in chemistry, biochemistry, or related fields, and are eager to make a significant contribution to the fields of natural products and screening of bioactives we encourage you to apply. PhD candidates joining this project will benefit from state-of-the-art research facilities, expert supervision, and the opportunity to engage with industry partners to translate their research findings into real-world impact.

BBSRC DTP students at the University of Nottingham benefit from a comprehensive training programme in research-related techniques to support their project and provide key transferable skills for a career in research.

For informal enquiries, please contact Prof Neil Oldham.  

Award Start Date            October 2024

Duration of Award          4 years

Terms and Conditions    

Home and international students are welcome to apply for this opportunity. Funding is available for four years from late September 2024. The award covers tuition fee (£4,712) at the home rate plus an annual stipend which was (£18,622) for 2023. This is set by the Research Councils. Please note that successful international candidates will be put forward for a University Fees Difference Scholarship to cover the difference between the home and international fee.

Informal enquiries may be addressed to neil.oldham@nottingham.ac.uk or bbdtp@nottingham.ac.uk

 

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