Back to search results

PhD Studentship: Developing Enabling Synthetic Methods for Accelerated Peptidomimetic Drug Discovery

University of Birmingham - School of Chemistry

Qualification Type: PhD
Location: Birmingham
Funding for: UK Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 6th December 2023
Closes: 6th March 2024

Transient protein-protein interactions (PPIs) control all cellular processes relevant to health and disease. Thus, a major problem in life-sciences research is to understand and manipulate PPIs with molecular and temporal resolution. Addressing this challenge will illuminate our understanding of disease development e.g. cell signalling in cancer and provide starting points for drug-discovery. Many PPIs employ peptides for recognition(1, 2) which represent viable and potentially powerful starting templates for designing PPI inhibitors. However, peptides have drawbacks, including conformational flexibility, poor proteolytic stability, and suboptimal cell uptake.

Our group has developed a number of enabling methods that include in silico tools,(3) constrained peptides,(1) protein or peptide-fragment hybrids(4, 5) and covalent backbone modification.(2) A key next step is to develop sustainable and higher throughput methods to prepare and screen peptidomimetics that exploit these capabilities. In this PhD project the student will explore novel synthetic methods for preparation and screening of peptidomimetics applied to focussed PPI modulator projects. Relevant targets include: SIM/SUMO, interactions of 14-3-3 proteins,(6) and interactions of Aurora A kinase(1) (all oncology). A range of techniques will be employed including: computational prediction, peptide chemistry, novel fragment-screening technologies and biophysics and structural-molecular biology.

You will join a vibrant, diverse and group of researchers to gain skills and knowledge in chemical and structural biology in its broadest sense, and, participate in our wider collaborative research.

Applications will be considered on an ongoing basis until suitable candidate(s) have accepted an offer. Applicants should contact Prof Andy Wilson (a.j.wilson.1@bham.ac.uk) for informal inquiries, and before applying (with a CV and cover letter summarising your research interests and previous experience). For more information, please see: https://ajwilsonresearch.com/

Funding notes:

We offer a fully-funded programme of integrated research and skills training with cross-disciplinary supervision. This studentship includes stipend and tuition fees paid at the UKRI level. Support for conference attendance and research materials will be available.

References:

1. R. S. Dawber, D. Gimenez, M. Batchelor, J. A. Miles, M. H. Wright, R. Bayliss and A. J. Wilson, ChemBioChem, n/a, e202300649.
2. E. E. Cawood, E. Baker, T. A. Edwards, D. N. Woolfson, T. K. Karamanos and A. J. Wilson, ChemRxiv, 2023, 10.26434/chemrxiv-22023-xglb26434-v26433.
3. S. Celis, F. Hobor, T. James, G. J. Bartlett, A. A. Ibarra, D. K. Shoemark, Z. Hegedüs, K. Hetherington, D. N. Woolfson, R. B. Sessions, T. A. Edwards, D. M. Andrews, A. Nelson and A. J. Wilson, Chem. Sci., 2021, 12, 4753-4762.
4. E. E. Cawood, N. Guthertz, J. S. Ebo, T. K. Karamanos, S. E. Radford and A. J. Wilson, J. Am. Chem. Soc., 2020, 142, 20845-20854.
5. Z. Hegedüs, F. Hóbor, D. K. Shoemark, S. Celis, L.-Y. Lian, C. H. Trinh, R. B. Sessions, T. A. Edwards and A. J. Wilson, Chem. Sci., 2021, 12, 2286-2293.
6. S. Srdanović, M. Wolter, C. H. Trinh, C. Ottmann, S. L. Warriner and A. J. Wilson, FEBS J., 2022, 289, 5341-5358.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from University of Birmingham

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge