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Research Associate in protein crystallography (Fixed Term)

University of Cambridge - Department of Biochemistry

Location: Cambridge
Salary: £36,024 to £44,263 per annum
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th December 2023
Closes: 7th January 2024
Job Ref: PH39738

The structural biology lab of Professor Marko Hyvonen is seeking a postdoctoral research associate to support ongoing projects at Bicycle Therapeutics employing structural biology and to develop tools to facilitate structure determination of proteins by X-ray crystallography and cryo-EM. The post-holder will generate biophysical and structural data for peptide-bound protein targets using x-ray crystallography, cryo-electron microscopy, surface plasmon resonance and ITC. The postholder will also be developing novel methods, through protein engineering, for empowering structural analysis of target proteins, be it for cryo-EM or crystallography.

You will be responsible for driving this academic-industrial collaboration on the structural and biophysical characterisation of bicyclic peptides in complex with therapeutic protein targets in immune-oncology and other debilitating diseases and for development of methods that enable complex targets to be analysed structurally. You will be in charge of the complete gene-to-structure pipeline. You will be in charge of design and generation of expression constructs of target proteins through protein production in bacterial, insect or mammalian cells. You will be responsible for structure determination of protein:inhibitor complexes by X-ray crystallography and by cryo-electron microscopy and for interaction analyses using various biophysical methods. You will provide analysis of the data you produce and contribute to the iterative design process of the peptides.

You should have a PhD from biochemistry, molecular biology, chemistry of closely related field with significant expertise in structural biology, in particular in protein crystallography, from your PhD and/or postdoctoral positions. You should have high level of analytical and problem-solving capability in protein biochemistry and structural biology and creative problem-solving skills.

The University of Cambridge is a signatory to the San-Francisco Declaration on Research (Assessment DORA), and in recruitment or promotion evaluations will assess research on the basis of its merits rather than the journal or venue in which it is published. Applicants should not include Journal Impact Factors or uncontextualized metrics in their applications. For more information: https://www.biology.cam.ac.uk/files/dora.pdf

Fixed-term: The funds for this post are available for 12 months in the first instance.

 

Informal enquiries can be sent to: Professor Hyvonen mh256@cam.ac.uk or Gustavo Bezerra gustavo.bezerra@bicycletx.com

For any questions about this vacancy or the application process please contact: personnel@bioc.cam.ac.uk

Please quote reference PH39738 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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