PhD Studentship: Transforming Respiratory Care at the Bedside Using Machine Learning Assisted On-Chip Vibrational Spectroscopy

PhD Supervisor: Senthil Murugan Ganapathy

Supervisory Team: Prof. Senthil Murugan Ganapathy

Project description

Acute respiratory distress syndrome (ARDS), a widespread respiratory condition affecting all ages, causes respiratory failure due to inflamed, fluid-filled lungs hindering gas exchange. COVID-19 highlighted ARDS globally, leading to hospitalizations and deaths. No specific therapy exists, and surfactant loss worsens outcomes, with 30-50% mortality. Oxygen therapy is crucial but excessive administration can damage tissues. Our study proposes on-chip spectroscopy for rapid in-vivo surfactant analysis, aiding precise treatments and prevention across all ages.

This PhD project is focused on transforming respiratory care at the bedside to develop a user-friendly, palmtop spectrometer that brings rapid bedside biomarker diagnosis within easy reach for clinicians. Building on our success in mid-infrared spectroscopy and machine learning, our team is creating a practical point-of-care device. Utilizing disposable enhanced spectroscopic chips, this project aims to analyse in-vivo surfactant metabolism swiftly. By doing so, clinicians can make informed decisions, stratify patients, and prescribe targeted therapies promptly.

Join us in shaping the future of respiratory diagnostics and making a real impact in healthcare.

Apply now and be part of a team committed to advancing solutions for respiratory challenges.

If you wish to discuss any details of the project informally, please contact Prof. Senthil Murugan Ganapathy, Email: smg@orc.soton.ac.uk, Tel: +44 (0) 2380 59 7811.

Entry Requirements

A very good undergraduate degree (at least a UK 2:1 honours degree, or its international equivalent).

Closing date

Applications are accepted throughout the year.

The start date will typically be late September, but other dates are possible.

Funding

For UK students, tuition fees and a stipend at the UKRI rate plus £2,000 ORC enhancement tax-free per annum for up to 3.5 years (totalling around £21,000 for 2024/25, rising annually). EU and Horizon Europe students are eligible for scholarships. CSC students are eligible for fee waivers. Funding for other international applicants is very limited and highly competitive. Overseas students who have secured or are seeking external funding are welcome to apply.

How To Apply

Apply online: Search for a Postgraduate Programme of Study (soton.ac.uk). Select programme type (Research), Faculty of Engineering and Physical Sciences, next page select “PhD ORC”. In Section 2 of the application form you should insert the name of the supervisor.

Applications should include:

• Curriculum Vitae
• Two reference letters
• Degree Transcripts/Certificates to date

For further information please contact: feps-pgr-apply@soton.ac.uk

The School of Zepler Institute is committed to promoting equality, diversity inclusivity as demonstrated by our Athena SWAN award. We welcome all applicants regardless of their gender, ethnicity, disability, sexual orientation or age, and will give full consideration to applicants seeking flexible working patterns and those who have taken a career break. The University has a generous maternity policy, onsite childcare facilities, and offers a range of benefits to help ensure employees’ well-being and work-life balance. The University of Southampton is committed to sustainability and has been awarded the Platinum EcoAward.

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