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PhD Studentship: NIHR Newcastle Biomedical Research Centre – Delineation of Pathological Mechanisms in Lewy Body Dementia

Newcastle University

Qualification Type: PhD
Location: Newcastle upon Tyne
Funding for: UK Students, EU Students, International Students
Funding amount: 100% tuition fees (paid at home rate) and a minimum annual stipend of £18,622 (2023/ 2024 UKRI rate) with support for research costs. International candidates will be required to fund the difference between the home and international fees
Hours: Full Time
Placed On: 1st February 2024
Closes: 15th March 2024
Reference: TC081

Award Summary

100% tuition fees (paid at home rate) and a minimum annual stipend of £18,622 (2023/ 2024 UKRI rate) with support for research costs. International candidates will be required to fund the difference between the home and international fees. 

Overview

Lewy body dementia (LBD) is the second most common form of neurodegenerative dementia after Alzheimer’s disease (AD), and is pathologically characterised by the accumulation of the protein α-synuclein into Lewy bodies. In addition to Lewy body formation, a number of other changes occur to the brain in LBD, including mitochondrial dysfunction and loss of vulnerable neuronal populations; however, the extent to which these diverse pathological mechanisms contribute to symptoms, or relate to one another, is not clear. Lack of clarity on the pathological mechanisms underlying LBD has impeded the development of disease-modifying therapies for patients. 

This PhD project aims to evaluate the association between pathological lesions, mitochondrial dysfunction and neuronal loss in LBD, and to determine their relationship to the clinical features of LBD. The successful candidate will gain skills in advanced neuropathological methods, automated analysis pipelines for neuropathological analysis, laser capture microdissection and analysis of DNA sequencing data.  

Number Of Awards: 1

Start Date: September 2024

Award Duration: 36 months

Application Closing Date: 15 March 2024

Sponsor: NIHR Newcastle Biomedical Research Centre 

Supervisors

Dr Daniel Erskine 

Professor Gavin Hudson 

Dr Lauren Walker 

Professor John-Paul Taylor 

Eligibility Criteria

You must have or be expected to gain a minimum 2:1 Honours degree or international equivalent in a subject relevant to the proposed PhD project. A master’s qualification will be advantageous. 

Applicants whose first language is not English require an IELTS score of 6.5 with a minimum of 5.5 in each subsection. International applicants may require an ATAS clearance certificate prior to obtaining their visa and to study on this programme.  

How To Apply

You must apply through the University’s Apply to Newcastle Portal 

In ‘Course choice’ tab, put ‘Postgraduate Research’ in 'Type of Study', ‘Full Time’ in ‘Mode of Study’, ‘2024’ in ‘Year of Entry’, code ‘8440F’ in ‘Course Title’, blank in ‘Research Area’. Press ‘Search’, select ‘PhD Translational and Clinical Research (FT)’, and save selection. 

Either upload a document or write into ‘Personal Statement’. Put code ‘TC081’ in ‘Studentship/Partnership Reference’. When prompted for research proposal, select ‘Write Proposal’. Type in the title of the research project from this advert. A research proposal is not required. You can also upload a covering letter and CV, please state how your interests and experience relate to the project.  

Degree transcripts/certificates and, if English is not your first language, a copy of your English language qualification if completed must be uploaded.  

Contact Details: daniel.erskine@newcastle.ac.uk 

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