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Senior Laboratory Research Scientist - Structural Biochemist

The Francis Crick Institute - Visual Biochemistry Lab, AZ-Crick-Alliance

Location: London
Salary: From £39,950 per annum with benefits, (subject to skills and experience)
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 8th February 2024
Closes: 8th March 2024
Job Ref: R1538
 

Location: The Francis Crick Institute, Midland Road, London 

Short summary

The AZ-Crick Alliance

AstraZeneca and the Francis Crick Institute have established a productive research collaboration, supporting discovery biology research and early translational projects since December 2016. 

The Team

A strong technical interest of the Enchev lab, at the Crick, complimentary and synergistic to the above biological and drug discovery interests, is to enable new avenues of studying biochemical process through the development and application of methods that allow the direct observation of biochemical processes at atomic spatial- and milliseconds time-resolution by combining microfluidics, cryo-electron microscopy (cryo-EM) and single particle analysis aided by machine learning.

Key Responsibilities 

The role of a Senior Laboratory Research Scientist in the Crick is diverse and rewarding.

The purpose of this role is to perform biochemical reconstitutions and structural studies relating to the project. Some of the specific aims include but are not limited to:

  • In vitro biochemical reconstitution of relevant POLQ constructs and substrates
  • Structural studies of above complexes by conventional cryo-EM and single particle analysis
  • Application of trEM workflows to the above and related complexes 

Key responsibilities will include but are not limited to:

  • Experimental design, execution and interpretation
  • Data documentation and regular internal presentations
  • Dissemination of scientific results through scientific conferences and publications

The post holder will be expected to creatively lead their own project. The ability to work in a team is essential. This is a unique opportunity to be part of a truly multi-disciplinary research programme, which will train the next-generation of scientific leaders, equipped to succeed both in academia and in industry. You will work with highly experienced colleagues and collaborators in an institute that values discovery without boundaries. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website.
  • Closing date is 08.03
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.
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