Back to search results

PhD studentship in mucus - Immortalizing Human Mucus Secreting Intestinal Goblet Cells to provide Mucus Factories

Newcastle University

Qualification Type: PhD
Location: Newcastle upon Tyne
Funding for: UK Students, EU Students, International Students
Funding amount: 100% of home fees paid and an annual stipend of £19,887 years 1 and 2, £20,086 year 3
Hours: Full Time
Placed On: 12th February 2024
Closes: 8th March 2024
Reference: BI083

Award Summary

100% of home fees paid and an annual stipend of £19,887 years 1 and 2, £20,086 year 3. A successful international candidate would be expected to fund the difference in fees. 

Overview

The project will investigate immortalization, characterization and commercialization of human derived, site specific mucus secreting goblet cells. 

Hypothesis 

That human mucus secreting goblet cells can be developed to produce site specific MUC 2, MUC 5AC and MUC 5B gene products. 

Background:  

Mucus protects absorptive surfaces. In the lung it provides the mucus elevator removing inhaled particulates. Mucus in the small and large intestine primarily comprises the product of the same MUC2 gene, however functionality and structure varies hugely between the two sites. 

Methodology 

This PhD will be conducted in collaboration with Newcastle Biobank/NHS, for collection of goblet cells from human biopsies which will be cultured, immortalised and characterised to validate their mucin secreting potential.  

Training provided 

The lab has an extensive record in aerodigestive physiology. The student will receive training in relevant techniques, and research skills from an experienced team. Through the supporting spin-out Aelius Biotech, the lab have a strong record of impact through commercialisation. 

Number Of Awards: 1

Start Date: 22nd April 2024 

Award Duration: The funding covers a three-year PhD 

Application Closing Date: 8th March 2024  

Sponsor: Aelius Biotech 

Supervisors

Professor Jeffrey Pearson - Institute of Biosciences Newcastle University.   

Dr Peter Chater - Aelius industrial supervisor  

Professor Chris Ward - Translational and Clinical Research Institute Newcastle University 

Eligibility Criteria

Applicants must have at least a 2.1 honours degree in an appropriate Bioscience related subject, e.g. Physiology, Biochemisty etc. 

Applicants whose first language is not English require an IELTS score of 6.5 overall with a minimum of 5.5 in each subsection.   

How To Apply

To apply for a studentship, you must register and apply through the University’s Apply to Newcastle Portal 

Once registered select ‘Create a Postgraduate Application’.  

Use ‘Course Search’ to identify your programme of study:  

  • please apply for the 2023 academic year for April 2024 start 
  • you can search for the ‘Course Title’ using the programme code: 8420F 
  • leave the ‘Research Area’ field blank  
  • select PhD Biosciences (FT)' as the programme of study 

You will then need to provide the following information in the ‘Further Details’ section:  

  • A ‘Personal Statement’ (this is a mandatory field) - upload a document or write a statement directly in to the application form  
  • The studentship code BI083 in the ‘Studentship/Partnership Reference’ field  
  • When prompted for how you are providing your research proposal - select ‘Write Proposal’. You should then type in the title of the research project from this advert - you do not need to upload a research proposal. 

 In addition, before you submit your application you will need to upload the following supporting documentation:  

  • covering letter and CV. The covering letter must state the title of the studentship, quote reference code BI083 and state how your interests and experience relate to the project   

Contact Details

For further details, please contact Professor Jeffery Pearson 

Newcastle University Bioscience Institute 

E-mail Jeffrey.Pearson@ncl.ac.uk 

Tel 0191208 6996 

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

PhD tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
 
More PhDs from Newcastle University

Show all PhDs for this organisation …

More PhDs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge