Back to search results

Research Associate / Senior Research Associate

University of Bristol - Faculty of Life Sciences

Location: Bristol
Salary: £37,099 to £46,974 (Grade I - J) per annum depending on experience
Hours: Full Time
Contract Type: Permanent
Placed On: 21st February 2024
Closes: 13th March 2024
Job Ref: ACAD107405

The role

Postdoc position to study Cell Competition in Human embryonic and progenitor cells

A postdoc position is available to study cell competition in human in vitro systems, including human cell lines, progenitor and embryonic stem cells. The positions are available in the lab of Professor Eugenia Piddini (https://piddinilab.org) with the goal to study the mechanisms of cell competition and how they impact tissue colonisation in health and in diseases like cancer. The lab is located at the University of Bristol, UK, and is funded by the Wellcome Trust and by Cancer Research UK.

Cell competition is a biological process akin to natural selection at the cellular level. Through cell competition, comparably less fit cells are eliminated and replaced by fitter cells and this acts as a quality control mechanism to remove damaged cells from tissues.

The main goals of the Piddini lab are to discover how cells compete and to design cell competition-based therapies in cancer and regenerative medicine. Our aim is to exploit cell competition to contain tissue colonization in cancer and to promote tissue colonisation in cell replacement therapies. Over the past decade our group has identified several pathways that modulate cell competition and implicated their role in tumour growth. We now aim to harness the molecular regulators of cell competition that we have discovered, to control cell competition in the development of novel anti-cancer or regenerative medicine therapies.

What will you be doing?

We aim to translate our cell competition discoveries into pre-clinically relevant models to develop cell-competition-enhanced cell replacement therapies and strategy to contain tumour growth. Current cells of interest include human embryonic cells and progenitor cells from various tissues, especially neural, hematopoietic and cardiomyocyte progenitors.

If you are a talented and highly motivated individual with expertise in cell biology, CRISPR genomic screening, stem cell biology, stem cell/iPS culture and you have an interest in cell therapy development we want to hear from you. 

You should apply if

We are looking to recruit a talented and highly motivated individual with expertise in cell biology and stem cell and/or developmental biology, molecular biology, signal transduction and imaging, culture of human progenitor and organoid cells from one or more of our tissues of interest e.g. neural, hematopoietic and cardiomyocyte progenitors. Additional experience in one or more of the following is desirable: generation of human iPS cells from primary cells, CRISPR/Cas9 mutagenesis, screening and knock-ins, culture of human retinal pigment epithelial cells or liver progenitor cells, quantitative cell biology and image analysis, next generation sequencing.

Applicants should be highly motivated and have a substantial track record of productivity & international experience. They should have a PhD in a relevant subject area or be close to completion of their degree.

The funds for these posts are available for 2 years in the first instance.

Additional information

Please contact Professor Eugenia Piddini eugenia.piddini@bristol.ac.uk,  including a CV and a brief statement outlining key areas of expertise and reasons why you would like to join our group.  Potential interview date is 15 April 2024.

Our strategy and mission

We recently launched our strategy to 2030 tying together our mission, vision and values.

The University of Bristol aims to be a place where everyone feels able to be themselves and do their best in an inclusive working environment where all colleagues can thrive & reach their full potential.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from University of Bristol

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge