Qualification Type: | PhD |
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Location: | Coventry |
Funding for: | UK Students, EU Students, International Students |
Funding amount: | Fully Funded with stipend |
Hours: | Full Time |
Placed On: | 26th February 2024 |
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Closes: | 25th April 2024 |
š„ Join the Frontier of Cardiovascular Healthcare
Cardiovascular diseases can cause severe clinical events and have consisted a leading cause mortality globally. The coronary artery disease (CAD) and coronary microvascular dysfunction (CMVD) are two major mechanisms of myocardial ischemia. Currently, the accurate diagnosis of CMVD depends on invasive measurement. Early detection and efficient treatment of CMVD are still challenging in clinical practice.
š Innovative Solutions: Computational Simulation of Nanomedicine
To meet the clinical need, patient-specific dynamic computational fluid dynamics (CFD) simulation has been developed for hemodynamic evaluation of CAD and CMVD. On the other hand, nanomedicines based on different nanoparticles have been developed for the detection and treatment of CAD and CMVD, where the personalized optimization of the treatment plan deserves further investigation. This approach not only streamlines the data-driven personalized cardiovascular medicine but also mitigates the burden on medical resources.
š” PhD Opportunity: A Step Towards Precise Cardiovascular Medicine for CMVD
In this PhD project, we aim to develop a novel computational method to achieve non-invasive, personalized optimization of nanomedicine for CMVD. Multimodal hemodynamic parameters will be derived from CFD simulation of the coronary circulation based on patient-specific radiological imaging data and physiological parameters. A multiphysics simulation model will be developed to investigate the features of nanomedicine distribution on microvascular level. Finally, the model will be validated on new clinical datasets to achieve reliable evaluation on the treatment efficacy of nanomedicine in patients with different severities of CAD and CMVD.
š Requirements and Expectations
We are looking for highly motivated candidates who have a strong interest in developing innovative healthcare technologies and has a broad understanding of cardiac physiology. The PhD project requires working with clinicians and computer scientists at different stages along the development pathway ā and will lead to high-quality publications. It will involve clinical data analysis, and a variety of computing work (including computational modelling, nanotechnology, and cardiology).
š Why Choose Us?
Entry criteria for applicants to PhDĀ
For further details please visit:Ā https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/research-entry-criteria/
https://www.coventry.ac.uk/research/research-opportunities/research-students/making-an-application/Ā
To find out more about the project, please contactĀ Haipeng Liu.
All applications require full supporting documentation, a covering letter, plus a 2000-word supporting statement showing how the applicantās expertise and interests are relevant to the project.
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