Postdoctoral Research Associate

Location: OCDEM, Churchill Hospital, Headington, Oxford, OX3 7LE

An exciting opportunity has arisen for a Research Associate position in the Prof David Hodson group within the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) (www.rdm.ox.ac.uk/people/david-hodson) on a prestigious UKRI Horizon Europe Guarantee Grant.

The successful applicant will assist in ongoing projects studying glucagon-like peptide-1 receptor (GLP1R) and gastric inhibitory polypeptide (GIP) receptor signaling using novel fluorescent probes and models. The project will focus on understanding where GLP1 and GIP receptors are localized, how they signal in complex tissue and how they contribute to cell heterogeneity. An important component of the studies will be to use advanced cell imaging, including confocal and super-resolution modalities. Projects will be complemented with human islets and pancreas sections where needed.

Although full training will be given in a variety of techniques, the person appointed will be expected to work independently on most tasks or in collaboration with the support of colleagues. Methods will include mouse genetics, cloning, CRISPR genome-editing, advanced imaging (confocal, STORM, STED), spatial transcriptomics, chemical biology and primary cell culture.

The position would suit a cell biologist with experience of imaging, molecular genetics and cell culture. A background in diabetes, metabolism or neuroscience is desirable, but not essential, as full support and training will be provided.

The position is full time and fixed term until 22^nd January 2028. The position will be based at OCDEM, Churchill Hospital, Headington, Oxford.

For informal enquiries, please contact Supprina Thebe at ocdem.personnel@ndm.ox.ac.uk. Please quote reference 171402 on all correspondence. As part of your formal online application, you will be required to upload a CV and supporting statement. Only applications received before midday on 4^th April 2024 can be considered. Interviews are scheduled for 24^th April 2024.

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