Location: | London |
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Salary: | £45,593 to £53,630 per annum |
Hours: | Full Time |
Contract Type: | Fixed-Term/Contract |
Placed On: | 5th March 2024 |
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Closes: | 1st April 2024 |
Job Ref: | MED04465 |
Job Summary
The research programme in molecular bacteriology, led by Prof. José R Penadés, will analyse the impact of phages in the emergence of antibiotic resistant bacteria. Bacteriophage-mediated gene transfer is a major evolutionary force occurring by two well-described mechanisms: generalized and specialized transduction. We have recently discovered that Staphylococcus and Salmonella phages engage in lateral transduction, the most powerful mode of transduction described to date. In this project, analysing important pathogens, we will investigate whether this ground-breaking strategy of gene transfer is widespread in nature. We anticipate that the results of this study will challenge basic and fundamental concepts of phage biology, which will be revisited here. Moreover, the proposed research has the potential to fundamentally restructure our understanding of the roles of bacteriophages in bacterial evolution, including the development of antimicrobial resistance and virulence in clinical strains.
Selected papers from the lab
Chee MSJ, Serrano E, Chiang YN, Harling-Lee J, Man R, Bacigalupe R, Fitzgerald JR, Penadés JR*, Chen J*. 2023. Dual pathogenicity island transfer by piggybacking lateral transduction. Cell 186:3414–3426.e16.
Fillol-Salom A, Rostøl JT, Ojiogu AD, Chen J, Douce G, Humphrey S, Penadés JR. 2022. Bacteriophages benefit from mobilizing pathogenicity islands encoding immune systems against competitors. Cell 185:3248-3262.e20.
Chen J, Quiles-Puchalt N, Chiang YN, Bacigalupe R, Fillol-Salom A, Chee MSJ, Fitzgerald JR, Penadés JR. 2018. Genome hypermobility by lateral transduction. Science 362:207–212.
Tormo-Más MÁ, Mir I, Shrestha A, Tallent SM, Campoy S, Lasa I, Barbé J, Novick RP, Christie GE, Penadés JR. 2010. Moonlighting bacteriophage proteins derepress staphylococcal pathogenicity islands. Nature 465:779–782.
Duties and responsibilities
Essential requirements
Further Information
This role is fulltime, fixed term for 12 months based at South Kensington Campus.
Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £40,694 - £43,888 per annum.
Should you require any further details on the role please contact: José R Penadés, j.penades@imperial.ac.uk
For technical issues when applying online please email sjobs@ic.ac.uk
Closing date: 01/04/2024
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