Senior Laboratory Research Scientist - Bonnet Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary

This position is available in Prof. Dominique Bonnet’s laboratory. The lab works on human normal and leukaemic stem cells and the role of the microenvironment as well as more recently the effect of pre-leukaemic mutation. https://www.crick.ac.uk/research/a-z-researchers/researchers-a-c/dominique-bonnet/

PROJECT SUMMARY

The lab is interested in understanding the regulation of the haematopoietic stem cells (which produce all the mature cells for the entire life of an individual), both in normal development and during leukaemia. We are specifically interested in the extrinsic mechanisms that regulate these cells and how we could intervene in order to eradicate the leukaemic stem cell. The main objective of the present funded project (CRUK early detection primer award) is to work with Dr Hector Huerga Encabo, senior post-doc in the group who will lead this study, in the characterisation of early traits of leukaemia. The aim of the present study is to identify specific immune cell subsets in the peripheral blood of individuals with preleukemic mutations.

Key Responsibilities

• Undertake laboratory research, developing the assigned project in a timely and resource efficient manner, as appropriate for the research area
• Provide technical input for the development, refinement and troubleshooting of relevant methodologies
• Make research initiatives and original contributions to the research programme wherever possible, and to contribute freely to the team research environment in a manner conducive to the success of the research project as a whole
• Design (following consultation with supervisor) and execute experiments
• Collect and analyse data
• Attend and participate in the lab’s academic activities, e.g. laboratory and journal club meetings, research group meetings
• Supervise and train where necessary new members of the research team 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 04.04.2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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