PhD Studentship: Gut Microbiome in Ageing - Is it the Answer to Leukaemia Progression

Primary supervisor - Dr Stuart Rushworth

Acute myeloid Leukaemia (AML) accounts for 85,000 deaths and it is estimated this will double by 2040. Presently AML remains incurable with a 5 year survival of less than 30%. AML is primarily a disease of the elderly, with three quarters of patients diagnosed after the age of 60 and presently the majority (75%) of these patients die within a year of diagnosis. In this project with access to human samples from AML patients the aim of this study is to determine the role of ageing induced changes in gut microbiota on driving/influencing the progression of AML.

The aim of this project is to define the metabolic mechanisms underpinning AML progression. Specifically, we will determine the role of changes in gut microbiota induced by ageing in these processes. To do this, the PhD student will learn in vivo techniques including animal handling, as well as isolation of samples from humans. The student will receive training in cellular biology methodologies including, DNA isolation, library preparation and sequencing as well as bioinformatic skills to analyse the acquired sequencing data.

 
The project will be carried out under the supervision of Dr Rushworth (Norwich Medical School). I have successfully supervised nine PhD students who immediately left for post-doctoral positions. Our lab is a supportive and collaborative environment, holds weekly lab meetings, biweekly journal club and encourages presentation at local, national and international meetings. Training provided will lead to the development of advanced research skills as well as other generic transferable skills.

The Microbes, Microbiomes and Bioinformatics (MMB) Doctoral Training Partnership (DTP) is open to UK and International candidates with relevant undergraduate degrees for entry in October 2024 and offers the opportunity to undertake a fully-funded 4-year PhD research project supported by the UKRI Medical Research Council in microbiology and microbial bioinformatics.

Our unique and comprehensive training programme empowers students to feel comfortable running sophisticated computer analyses alongside laboratory work and emphasises problem-based learning in microbial bioinformatics, professional development and research skills. All MMB DTP students undertake a Professional Placement.

Interviews for shortlisted candidates will take place on Wednesday 15 May 2024.

The MRC DTP is committed to equality, diversity and inclusion. Students are selected without regard to age, disability, gender identity, marriage or civil partnership, pregnancy or maternity, ethnicity, religion or belief, sex or sexual orientation or social background. We value curiosity, independence of thought, plus an aptitude for research that combines laboratory work and bioinformatics.

For information on eligibility and how to apply: www.uea.ac.uk/phd/mmbdtp

Additional Funding Information

This project is awarded with a 4-year fully-funded studentship including direct payment of tuition fees to the University, stipend for living expenses (2023/4 rate: £18,622) and a Research Training Support Grant for each year of the studentship. 

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