Senior Laboratory Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

The post-holder will work in the Experimental Histopathology STP, providing advice, training, and expertise in a range of techniques to analyse cells and tissues from experimental models and human tissue.

Experimental Histopathology (EHP) is a Science Technology Platform (STP) within the Crick, providing a comprehensive and interactive centre for the histology-based analysis of experimental tissues and human bio resources/clinical trials, with the aim of relating experimental models to the pathology of human disease.

Their time will be spent in the lab, where they will support multiple tasks, but will have responsibility for consulting collaboratively and performing Immunohistochemical (IHC), multiplex Immunofluorescence (mIF) and RNAScope on a wide variety of experimental tissues, (both paraffin, frozen and other formats). This will include antibody optimisation and high-plex staining on Leica Bond RX platforms. The post holder will also be involved in new technology development and must be proactive, exceptionally well organised, motivated and an excellent team-player with a extensive experience in project management and troubleshooting.

Key Responsibilities

• Exemplifying and maintaining standards for the service
• Supporting and contributing to existing projects through effectively and efficiently performing established techniques
• Conducting experimental work autonomously and by own initiative on projects as agreed with the deputy and STP Lead
• Operating as a technical specialist in IHC/mIF and ISH (RNAScope) staining and spatial transcriptomics staining projects
• Interacting with and consulting collaboratively with researchers to help plan experiments
• Liaising with other members of the EHP team; actively supporting and training team members to develop their skills and promote collective success
• To provide specialised training to researchers, visitors, and other Crick staff when necessary
• Use of knowledge to build on existing methodologies and innovate through Identification, assessment and development of new technologies 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 24/04/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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