Research Associate

Location: Hammersmith Campus 

Job Summary 

We are looking for a PhD graduate to join our group in order to map actionable cholesterol binding sites in the glucagon-like peptide-1 receptor (GLP-1R) and in the glucagon receptor (GCGR), using state-of-the-art high throughput screening techniques including deep mutational scanning coupled with mass-spectrometry analysis and directed evolution approaches. 

Duties and responsibilities

• You will perform high-throughput screening experiments on mutant libraries to map the importance of each amino acid in the GLP-1R and the CGCR for cholesterol binding.
• You will also participate in the development of a new method to apply a directed evolution approach based on vaccinia virus libraries to generate evolved receptors with the desired cholesterol binding capabilities.

Essential requirements

• PhD in molecular cell biology or related subject.
• Previous experience in glucagon receptor subfamily.
• Previous experience in studying GPCR – lipid interactions.
• Experience in validating receptor cholesterol binding sites.
• Previous experience in pancreatic beta cell and islet biology.

Further Information

This post is full time, fixed term for 2 years and you will be based at Hammersmith Campus.

Should you require any further details on the role please contact: Dr Alejandra Tomas – a.tomas-catala@imperial.ac.uk

Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £40,694 - £43,888 per annum.

Hybrid working may be considered for this role. Staff working in roles that are suitable for hybrid working will normally be expected to work 60% of their time onsite. The opportunity for hybrid working will be discussed at interview.

More information is available on the following web page: Work Location Framework | Administration and support services | Imperial College London

Closing date: 25 April 2024

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