Research Associate in Mass Spectrometry-based Metabolomics of Traumatic Injury and associated Cardiometabolic Risk

Location: Hammersmith Hospital Campus 

Job Summary 

An exciting Research Associate position has opened to discover metabolic mediators associated with traumatic combat injuries and their relationship with cardiometabolic risk and premature ageing. 

We are looking for a Postdoctoral Research Associate in Mass Spectrometry – based Metabolomics to join the Division of Systems Medicine headed by Prof. Dumas and characterise the human metabolome in relation to traumatic combat injuries as part of the ADVANCE study. The postholder will undertake a high-resolution mass spectrometry-based of the metabolome of the ADVANCE volunteers. 

Duties and responsibilities 

The project includes optimisation of chromatographic and mass spectrometric conditions, metabolite identification, development of a comprehensive standards database and metabolomic analysis in human biofluids. The project will focus particularly on global profiling of the human metabolome in various matrices. They will contribute to developing and implementing ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) to profile the metabolome, enhance metabolite identification and how these metabolites contribute to the signature of injury and associated cardiometabolic risk. The project will have a special focus on i) identification of metabolites involved in the signature of injury, ii) assessing how the metabolome captures injury heterogeneity, iii) defining how the metabolomic model injury relate to cardiometabolic risk, iv) how injury differentially affects the metabolome with age. 

The postholder will play a role in influencing the project. Based on findings, the role may include development of new analytical, chemoinformatic or bioinformatic workflows, management, and population of pure chemical standards databases and/or biological mechanism hypothesis generation. 

The postholder will also help coordinate metabolomics activities among projects within the Division of Systems Medicine, helping with data generation and integration with other omics datasets produced as part of the section and division activities. 

Essential requirements

• You must have a PhD in Analytical Chemistry, Biochemistry or related field with a strong expertise in mass spectrometry for metabolomics.
• You will need to have experience in interdisciplinary research and managing large integrated development projects.

Further Information 

The contract is full-time for 18 months 

For informal inquiries or questions about the role, please contact Prof Marc-Emmanuel Dumas directly at m.dumas@imperial.ac.uk 

For technical issues when applying online please email sjobs@ic.ac.uk 

To apply, click the 'Apply' button above.

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