Postdoctoral Research Assistant: Chemistry Approaches to Probe E3 Ligase Mechanism and Function

Applications are invited for a Postdoctoral Research Assistant in the chemical biology lab of Professor Satpal Virdee. The project will develop innovative and urgently needed tools for studying the ubiquitin system. The ubiquitin system is a central regulator of the cell containing a wealth of undiscovered aspects and untapped therapeutic potential. Working at the interface of chemistry and biology is an essential strategy for driving this exciting field of research forward (Squair & Virdee Nat Chem Biol, 2022). The project will apply chemical protein synthesis methods to develop next-generation protein sensors of E3 ligase enzymes and/or tools for investigating non-canonical ubiquitination (Pao et al., Nat Chem Biol, 2016; Pao et al., Nature, 2018; Mathur et al., Cell Chem Biol, 2020; Squair & Virdee, Nat Chem Biol, 2022). The successful applicant will benefit from working in a multidisciplinary lab equipped for chemistry and biology to the highest standard. The post will provide excellent career development opportunities. For further details, please consult http://www.ppu.mrc.ac.uk

Passionate candidates should ideally have recently carried out a PhD working in chemistry-related area. The position will be a fantastic opportunity for candidates to broaden their skillset by working in a multidisciplinary lab using state- of-the-art technologies. Coupled with this exciting area of biological focus, the project offers an excellent opportunity for career development with mentoring support to reach career aspirations. The successful applicants will join an international team in an exciting and interactive environment, equipped to the very highest standards with generous consumable support.

Your priorities will include:

• Plan and carry out chemical biology experiments under supervision
• Presentation of research at lab meetings and scientific meetings
• Preparation of data for manuscript preparation
• Liaise with lab members and collaborators
• Maintenance of meticulous lab records
• Upkeep of chemistry facilities

Who we’re looking for:

Passionate candidates should ideally have recently carried out a PhD working in biochemistry, structural biology or cell biology.

• Experience chemistry-related discipline (e.g. chemical biology, peptide chemistry, medchem)
• A desire to learn more about the ubiquitin system

This contract is for a fixed term period of 3 years with the possibility of extension. The closing date for applications is 11th May.

MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU):

The MRC PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world-leading researchers in the field of signal transduction have trained within the MRC PPU. The major aims of the MRC PPU are to advance understanding of the role of protein phosphorylation and

ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. A key remit of the MRC PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research.

School of Life Sciences (SLS):

The MRC PPU is based within the School of Life Sciences at the University of Dundee, a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.