Postdoctoral Fellow – H Yardimci Lab

Location: The Francis Crick Institute, Midland Road, London

Short summary

Our laboratory investigates processes involved in eukaryotic DNA replication and genome maintenance using conventional biochemistry and single-molecule visualization tools. To study eukaryotic replication, we use a number of model systems including Xenopus egg extracts and a reconstituted system with purified human proteins. The group currently consists of around 6 researchers including PhD students, postdoctoral fellows and laboratory research scientists. For more information, please see the laboratory website. 

We aim to unravel the intricate mechanisms of eukaryotic DNA replication machinery as it maneuvres through the chromatin landscape, shedding light on the processes that ensure accurate genome duplication. Employing the precision of single-molecule fluorescence microscopy, we can observe replisome dynamics unfold in real time. Previous work in our lab has shed light on the interplay between DNA replication and essential chromatin processes, including parental histone recycling (Gruszka et al, 2019. Sci Adv) and the establishment of sister chromatid cohesion (Cameron et al, 2024. Science). Building on these foundations, our current project seeks to elucidate the molecular intricacies of these interactions, potentially revolutionizing our understanding of genomic fidelity. 

Informal enquiries are welcome, and should be directed to Hasan Yardimci (Hasan.Yardimci@crick.ac.uk). 

Key Responsibilities

The post holder should embody and demonstrate our core Crick values: bold, imaginative, open, dynamic and collegial, in addition to the following: 

Essential

• PhD (including but not limited biochemistry and biophysics) or in the final stages of PhD submission
• Strong interest in genome maintenance
• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings
• Excellent organisational and communication skills
• Ability to work independently and also capable of interacting within a group 

Desirable

• Experience in protein biochemistry
• Experience in working with nucleic acid processing enzymes
• Experience in single-molecule methods including TIRF microscopy 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 23^rd May 2024.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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