GeMS Research Scientist--in-- Genetic Manipulation –Team

Location: The Francis Crick Institute, Midland Road, London

Short summary

Animal models provide an important means to determine gene function and model disease.  The BRF are providing expertise and support for housing and experiment, all underpinned with world-class standards of welfare.  Within the BRF, Genetic Modification Services (GeMS) provide a breadth of specialist skills and resources for the design, creation, production, storage and use of genetically altered animals, germplasms and cell lines together with ancillary techniques.

The GeMS Research Scientist (RS) post holder will participate in the creation of new animal models, taking a lead role towards the development of a subset of projects. As such, you will be expected develop a detailed understanding of genetic modification and mouse genetics and will be expected to follow breeding progress ensuring that the 3R’s principles for in vivo research (replacement, reduction and refinement) underpins all work that is undertaken.

Key Responsibilities

• Assist in the design, generation of reagents and validation of new genetically modified alleles.
• Perform core molecular biology techniques including LR-PCR, PCR, digital droplet or qPCR, molecular cloning, NGS sequencing technologies, genotyping and sequence analysis.
• Maintenance of mouse embryonic stem cultures and perform in vitro CRISPR facilitated and classical gene targeting experiments using electroporation, nucleofection and lipofection. Engage in out of hours cell culture work rota.
• Participate in the creation of new animal models, taking a lead role towards the development of a subset of projects; working towards agreed deadlines, identifying and troubleshooting at each step, seeking support when required.
• Maintain records, ensuring your own scientific work is always carried out accurately and efficiently, adhering to legal frameworks.
• Awareness and promotion of all relevant health and safety guidance and legislation.
• Ensure compliance to appropriate SOPs and best practice. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

• If you are interested in applying for this role, please apply via our website.
• The closing date for applications is 16/06/2024
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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