Postdoctoral Project Research Scientist

Location: The Francis Crick Institute, Midland Road, London

Short summary

The Postdoctoral Project Research Scientist role is to provide support to interlinked projects within the Sahai group. We are seeking to understand the tumour microenvironment of metastatic disease and how it might be targeted for therapeutic benefit. Particular attention will be paid to cancer-associated fibroblasts the extracellular matrix.

Dr Sahai’s laboratory focuses on how the tumour microenvironment influences the spread of cancer and how it responds to therapies. Details of research projects currently being undertaken can be seen at:  https://www.crick.ac.uk/research/labs/erik-sahai

The research aims to understand the stromal microenvironment of metastases and how it can be targeted. In this project, some of the specific aims could include but not be limited to:

• Spatial analysis of the tumour microenvironment using highly multiplexed immunostaining
• Analysis of responses to targeted, radiotherapy, and immunotherapies
• Establishment and analysis of co-culture models of the tumour microenvironment

Postdoctoral Project Research Scientists are expected contribute to between 1 and 2 projects at any one time on a collaborative basis (both in the lab and with external collaborators). They are expected to be able to plan, execute, and interpret experiments and steer the long-term direction of projects in cooperation with the group leader. The ability to work in a team and communicate with other teams is essential.

Key Responsibilities

• Collaborating with other lab members on research projects.
• Providing experimental or technical support to other lab members.
• Providing technical expertise for the development, refinement and troubleshooting of relevant methodologies.
• Design and execute experiments using transient- and viral-based expression systems to modulate the activity/expression of target proteins
• Participating in academic activities, including group meetings and journal clubs, seminars,
• Organisation and management of the laboratory, including maintaining laboratory databases, ordering of laboratory supplies, monitoring, and routine maintenance of equipment. 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council, Cancer Research UK, Wellcome, UCL, Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy.

• If you are interested in applying for this role, please apply via the ‘Apply’ button above.
• All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom.

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