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Postdoctoral Fellow - Adrover Lab

The Francis Crick Institute

Location: London
Salary: From £43,210 subject to skills and experience, with benefits
Hours: Full Time
Contract Type: Fixed-Term/Contract
Placed On: 3rd June 2024
Closes: 30th June 2024
Job Ref: R1733
 

Location: The Francis Crick Institute, Midland Road, London

Short summary 

Dr. Adrover’s laboratory focuses on how cancer affects whole-body physiology, with a particular emphasis on the cardiovascular, haematopoietic, and immune systems.

Key Responsibilities

The Cancer Macroenvironment Lab is seeking applications for postdoctoral candidates to carry out experimental work aimed at understanding the interplay between cancer as a systemic disease and cardiovascular disease. The research program will study how cancer affects the haematopoietic stem cell compartment to induce changes in myeloid populations that can explain the abnormally elevated cardiovascular disease of cancer patients.

In this project, some of the specific aims include but are not limited to:

  • Using murine models of cancer to analyse the hematopoietic stem and progenitor cell compartment in the bone marrow to understand how the tumour induces changes in neutrophil phenotypes and functions.
  • Interrogating the role of neutrophils and other innate immune populations in murine models of cardiovascular disease, including models of thrombosis and acute myocardial infarction, to dissect the role of cancer-imposed changes to the immune compartment in cardiovascular disease outcome.
  • Using state of the art in vivo intravital imaging techniques to study the intravascular behaviour of neutrophils in tumour-bearing mice.

Postdoctoral Fellows will lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. 

Key experience and competencies 

  • PhD in immunology, cancer biology, biochemistry or cell biology or in the final stages of PhD submission
  • Knowledge and experience in immunology or cancer biology
  • Technical expertise in mouse work and microscopy, and experience with experimental design
  • Track record of writing papers as evidenced by publications or submitted manuscripts in peer-reviewed journals 

About us

The Francis Crick Institute is a biomedical discovery institute dedicated to understanding the fundamental biology underlying health and disease. Its work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections, and neurodegenerative diseases.

An independent organisation, its founding partners are the Medical Research Council (MRC), Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King’s College London.

The Crick was formed in 2015, and in 2016 it moved into a new state-of-the-art building in central London which brings together 1500 scientists and support staff working collaboratively across disciplines, making it the biggest biomedical research facility under in one building in Europe.

The Francis Crick Institute will be world-class with a strong national role. Its distinctive vision for excellence includes commitments to collaboration; developing emerging talent and exporting it the rest of the UK; public engagement; and helping turn discoveries into treatments as quickly as possible to improve lives and strengthen the economy. 

  • If you are interested in applying for this role, please apply via our website.
  • The closing date for applications is 30/06/2024
  • All offers of employment are subject to successful security screening and continuous eligibility to work in the United Kingdom. 
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