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PhD Studentship: Understanding how Redox Regulation Processes Facilitate Platelet Activation

University of Surrey

Qualification Type: PhD
Location: Guildford
Funding for: UK Students
Funding amount: Not Specified
Hours: Full Time
Placed On: 4th June 2024
Closes: 1st July 2024
Reference: PGR-2324-097

Platelets are tiny circulating blood cells which prevent bleeding from damaged blood vessels (haemostasis) by becoming active at the site of injury. In addition to this crucial role, platelets can be activated inappropriately (thrombosis) leading to heart attack or stroke.

Platelets release a range of redox-active substances which can bind to adjacent platelets and mediate chemical changes to surface receptors to modulate downstream cell signalling. The successful student will investigate how these platelet-released substances regulate platelet signalling pathways and how this can be targeted for the development of better therapies.

 This project will equip the student with skills in a wide range of techniques including the use of specialist tests of platelet function, cell migration, cell and molecular biology assays, mass spectrometry and microscopy.

Supervisors: Dr Lisa Holbrook and Dr Ioannis Smyrnias

Entry requirements

Open to candidates who pay UK/home rate fees. See UKCISA for further information. Starting in October 2024. Later start dates may be possible, please contact Dr Lisa Holbrook once deadline passes.

You will need to meet the minimum entry requirements for our PhD programme.

Applicants should have a first-class or upper second-class honours or equivalents in Biochemistry, Biomedical Sciences, Biomedical Engineering, Biological Sciences, Physiology, or similar subjects.

Practical experience of cell biology, platelet biology or cell signalling is desirable but not essential.

How to apply

Applications should be submitted via the Veterinary Medicine and Science PhD programme page.

In place of a research proposal, you should upload a document stating the title of the project that you wish to apply for and the name of the relevant supervisor.

Applicants are encouraged to contact Dr. Lisa Holbrook (l.holbrook@surrey.ac.uk) to discuss the project informally prior to applying.

Funding

Fully and directly funded for this project only. Funding is for 3.5 years.

Enquiries: Contact Dr Lisa Holbrook

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