Back to search results

Research Associate in Epigenomics UK Dementia Research Institute

Imperial College London - Faculty of Medicine

Location: London, Hybrid
Salary: £48,056 to £56,345 per annum
Hours: Full Time
Contract Type: Permanent
Placed On: 6th September 2024
Closes: 25th September 2024
Job Ref: MED04725
 

Applications are invited for a Research Associate in vascular-immune epigenomics to join the lab of Dr Alexi Nott in the UK DRI at Imperial.

About the role

Applications are invited for a Research Associate in vascular-immune epigenomics to join the lab of Dr Alexi Nott (https://nottgroup.com/index.html) in the UK DRI at Imperial.

Following a new award from the Alzheimer’s Association, you will lead one or more projects to characterise the epigenome of vascular-immune cell types in Alzheimer’s disease using patient-derived samples.  Based on the White City Campus under the guidance of Dr Alexi Nott, you will profile the epigenome and chromatin architecture of brain-derived vascular and immune cell types. You will contribute to the design and generation of large-scale ‘omics datasets with a primary focus on epigenomic analysis at single nuclei resolution to address major research questions relevant to Alzheimer’s disease and vascular pathology.

Today, over 1 million people in the UK are living with dementia and related neurodegenerative disorders, such as Alzheimer’s disease. The impact of these incurable and progressive conditions on individuals and their families is devastating. The cost to the economy and public services is large and growing as the UK population ages.

We are a globally leading multidisciplinary research institute of over 900 staff investigating the spectrum of neurodegenerative disorders causing dementia, driving a step change in our understanding of neurodegeneration, and accelerating the discovery, development and delivery of interventions that will help diagnose, treat, and ultimately prevent dementia.

Please contact Dr Alexi Nott a.nott@imperial.ac.uk for further discussion about the project and role.

What you would be doing

Using your experience in single nuclei (epi)genomics of the brain, you will:

  • Generate single-nuclei CUT&Tag data from patient-derived brain tissue and stem cell model systems.
  • Work collaboratively as part of a multidisciplinary research team.

What we are looking for

  • Experience of nuclei isolation, preferentially from brain and/or human tissue
  • Experience of fluorescence-activated nuclei sorting (FANS), and/or FACS
  • Experience of epigenomics and/or single-cell genomic technologies.
  • Research Associate: Hold a PhD (or equivalent) in neuroscience, biological sciences, or a closely related discipline, or equivalent research or industrial experience . *Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £41,694 - £44,888 per annum

What we can offer you

This role is part of the UK Dementia Research Institute (UK DRI) at Imperial College London, located in the Department of Brain Sciences.  Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:

  • Access to a range of cutting-edge technologies.
  • An inclusive and collegial working environment with the opportunity to mentor, supervise and teach students.
  • Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
  • Support from the Postdoc and Fellows Development Centre (PFDC) and Imperial and UK DRI ECR Communities.
  • The opportunity to continue your career at a world-leading institution
  • Sector-leading salary and remuneration package (including 39 days off a year)

Further information

This is a full time and fixed-term role for two years based at the White City Campus.

Applicants are encouraged to contact Dr Alexi Nott (a.nott@imperial.ac.uk) for an informal discussion about the project and the role.

We value your feedback on the quality of our adverts. If you have a comment to make about the overall quality of this advert, or its categorisation then please send us your feedback
Advert information

Type / Role:

Subject Area(s):

Location(s):

Job tools
 

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Ok Ok

PhD Alert Created

Job Alert Created

Your PhD alert has been successfully created for this search.

Your job alert has been successfully created for this search.

Manage your job alerts Manage your job alerts

Account Verification Missing

In order to create multiple job alerts, you must first verify your email address to complete your account creation

Request verification email Request verification email

jobs.ac.uk Account Required

In order to create multiple alerts, you must create a jobs.ac.uk jobseeker account

Create Account Create Account

Alert Creation Failed

Unfortunately, your account is currently blocked. Please login to unblock your account.

Email Address Blocked

We received a delivery failure message when attempting to send you an email and therefore your email address has been blocked. You will not receive job alerts until your email address is unblocked. To do so, please choose from one of the two options below.

Max Alerts Reached

A maximum of 5 Job Alerts can be created against your account. Please remove an existing alert in order to create this new Job Alert

Manage your job alerts Manage your job alerts

Creation Failed

Unfortunately, your alert was not created at this time. Please try again.

Ok Ok

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

Create PhD Alert

Create Job Alert

When you create this PhD alert we will email you a selection of PhDs matching your criteria.When you create this job alert we will email you a selection of jobs matching your criteria. Our Terms and Conditions and Privacy Policy apply to this service. Any personal data you provide in setting up this alert is processed in accordance with our Privacy Notice

 
 
More jobs from Imperial College London

Show all jobs for this employer …

More jobs like this
Join in and follow us

Browser Upgrade Recommended

jobs.ac.uk has been optimised for the latest browsers.

For the best user experience, we recommend viewing jobs.ac.uk on one of the following:

Google Chrome Firefox Microsoft Edge