Postdoctoral Research Associate in Biochemistry and Structural Biology

Location: Department of Biochemistry, South Parks Road, Oxford OX1 3QU

About the role 

Dr. Frank Bürmann leads a research group investigating the molecular mechanisms of chromosome remodelling. The team employs biochemical reconstitution, electron cryomicroscopy (cryo-EM), and advanced bacterial genetics to explore how cells control the three-dimensional structure of DNA. We investigate how structural maintenance of chromosomes (SMC) complexes shape chromosomes by DNA loop extrusion, how they cooperate with DNA topoisomerases, and how bacteriophages and other infective agents manipulate host chromosomes and defences. 

We are seeking a motivated and skilled Postdoctoral Research Associate in biochemistry and structural biology to join our expanding team. This is an exciting opportunity to contribute to pioneering research at the forefront of structural chromosome biology. You will investigate the molecular mechanisms of SMC complexes using cryo-EM, with the aim of directly visualising their activities. You will employ a multi-disciplinary approach, including protein/nucleic acid biochemistry and bacterial genetics, to test and generate hypotheses. You will develop new ideas and approaches and provide guidance to less experienced members of the team. 

This full-time fixed-term post is funded by the Wellcome Trust for up to 4 years in the first instance. 

The actual starting salary offered will be based on qualifications and relevant skills acquired and will also be determined by the funding available. 

What We Offer 

Your happiness and wellbeing at work matters to us, so we offer a range of family friendly and financial benefits including: 

• An excellent contributory pension scheme
• 38 days annual leave
• A comprehensive range of childcare services
• Family leave schemes
• Cycle loan scheme
• Membership to a variety of social and sports clubs
• Discounted bus travel and Season Ticket travel loans 

The University also runs an enormous amount of social groups and sports clubs for those looking for more than just a great place to work. 

About you 

You will hold, or be near completing, a PhD/DPhil degree in a relevant biological discipline. Good communication and documentation skills, and the ability to work effectively as part of a team are essential. You will be self-motivated, creative, and persistent, with a proven ability to address challenging research questions. You will have experience in protein chromatography, recombinant DNA techniques, and quantitative data analysis. The research involves cryo-EM sample preparation, data acquisition, and analysis, so experience in these areas would be advantageous. 

Application Process 

Applications for this vacancy are to be made online via the 'Apply' button above and Vacancy ID 175961. You will be required to upload your curriculum vitae and a supporting statement, setting out how you meet the selection criteria for the post, using examples of your skills and experience. As part of your application, you will be asked to provide details of two referees and indicate whether we can contact them now. 

For further details, please refer to the How to apply section of the job description. Any further enquires may be directed to recruitment@bioch.ox.ac.uk. 

The closing date for applications is 12:00 noon on Monday 18th November 2024. Only applications received before this time can be considered. interviews for shortlisted candidates to be held on as soon as possible thereafter. 

Committed to equality and valuing diversity

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