Senior/Principal Laboratory Research Scientist: Metabolomics & Lipidomics Specialist  

Location: The Francis Crick Institute, London

Salary: SLRS level from £45,700 /PLRS level from £55,555 pa plus benefits.

About us…  

The Francis Crick Institute is Europe’s largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. 

To learn more, click here.

About the role…  

This role in the Metabolomics Scientific Technology Platform (STP) will cover both targeted and discovery metabolomics in the context of biological research. The post provides a unique opportunity to work with cutting edge metabolomics techniques and to become deeply involved in the diverse biological research across the Crick. 

Key elements include LC-MS based metabolomics and lipidomics, including independent operation of the state-of-the-art LC-MS instrumentation (most notably Thermo Orbitrap and Agilent triple quadrupole instruments), along with GC-MS studies. 

What you will be doing…  

As an S/PLRS at the Crick, you will:  

• Metabolomics, lipidomics, and mass spectrometry operations (40%). Efficient operation and maintenance of mass spectrometers – particularly liquid chromatography-mass spectrometry (LC-MS), but also gas chromatography-MS (GC-MS). Effective performance and development of in house-established metabolomics procedures.
• Data analysis (35%). Effectively use data analysis software to process raw mass spectrometry data and analyse both targeted and large-scale metabolomics datasets, including statistical analysis (i.e. univariate and multivariate analyses.  
• Training (15%). The post holder will be responsible for training other Crick researchers in the operation of the LC-MS & GC-MS instrumentation.
• Laboratory management (10%). The post holder will be responsible for successful day to day operation of the laboratory, including maintenance of safety standards, purchasing, and general organisation, among others.  

About you…   

The essential criteria you will bring…  

• Ph.D. or equivalent, in Metabolomics, Biochemistry, Analytical Chemistry, Statistics, Mathematical Modelling, or related discipline. 
• Evidence of significant experience in metabolomics (including lipidomics). 
• Evidence of significant experience in operation, maintenance, and troubleshooting of hyphenated-mass spectrometry (in particular, LC-MS & GC-MS). 
• Experience in performance of metabolomics/lipidomics experiments (including experimental design, metabolite extraction, sample preparation, data acquisition, and method development).
• Experience in mass spectrometry and metabolomics/lipidomics data analysis and statistics (including targeted and profiling approaches, and concepts such as univariate and multivariate analyses, power calculations, and significance) and use of data analysis software and workflow packages. 
• Knowledge of experimental design and metabolomics procedures in the context of large cohort studies.  

To see the complete job description, click here.  

Learn more about Metabolomics click here.  

About Working at the Crick… 

Our values  

• We are bold. We make space for creative, dynamic and imaginative ideas and approaches.
• We are open. We’re highly collaborative and interactive, and make sure our activities are visible to the outside world. 
• We are collegial. We show respect for one another, work cooperatively and support the wider community. 

At the Crick we believe that diversity and inclusion are essential to driving innovation and scientific discovery.

We are a Disability Confident employer. Please contact nicola.gyte@crick.ac.uk for assistance.

Read more about our EDI approach here.   

What will you receive?  

We value our team members and offer an extensive range of benefits. You can find out more here.

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