Postdoctoral Researcher - Therapeutic Resistance in Brain Cancer

We are seeking a highly motivated and ambitious Postdoctoral Researcher to join our team in addressing a key question in cancer biology: why brain cancer cells resist current therapies. This role offers a unique opportunity to investigate the mechanisms of therapeutic resistance in glioblastoma and contribute to the development of more effective treatment strategies.

Our research focuses on understanding how tumour cell plasticity and dynamic cell state transitions drive resistance, and aims to identify actionable vulnerabilities that could inform future therapies.

You will work with cutting-edge models and technologies—including patient-derived glioblastoma organoids, CRISPR-based screens, mass cytometry, and advanced microscopy—to dissect these complex biological processes.

You will be responsible for managing your own academic research, collaborating with computational and clinical researchers, and contributing to the scientific development of the lab. This is an exciting opportunity for a researcher passionate about translational cancer research and making a meaningful impact in the field.

 

 

You will hold a PhD (or be close to completion) in a relevant field such as cancer biology, molecular biology, medicine, or neuroscience. Your expertise will include molecular biology techniques, advanced microscopy, quantitative image analysis, and primary tissue culture, all of which will support your contributions to high-quality, translational cancer research.

You will have a strong track record of research excellence, including first-author publications in peer-reviewed journals, and demonstrate the ability to manage complex projects, analyse large datasets, and deliver results to tight deadlines. Your collaborative mindset and excellent communication skills will enable you to work effectively within an interdisciplinary team and present your findings confidently to both academic and clinical audiences.

Experience or interest in applying interdisciplinary approaches and additional expertise in areas such as FACS/mass cytometry, bioinformatics, or in vivo work (holding a personal licence) would be advantageous.

 

 

If you would like to discuss this role, please contact Dr Lucy Brooks at  lucy.brooks@oncology.ox.ac.uk . You will be required to upload a supporting statement (setting out how you meet the selection criteria), a curriculum vitae, and the names and contact details of two referees as part of your online application.

 

The closing date for applications is noon on Monday, 16th June 2025.

 

 

As an employer, we genuinely care about our employees' wellbeing and this is reflected in the range of benefits that we offer including:

• An excellent contributory pension scheme

• 38 days annual leave

• A comprehensive range of childcare services

• Family leave schemes

• Cycle loan scheme

• Discounted bus travel and Season Ticket travel loans

• Membership to a variety of social and sports clubs

 

Type / Role:

Subject Area(s):

Location(s):